| abstract |
A substantially water-free bulk parenteral solution consisting of an anhydrous liquid melatonin preparation containing at least: a) melatonin (MLT) quantitatively at a concentration equal to or greater than 10.0% weight / volume of the bulk solution; b) a polyethoxy derivative (PED) selected from macrogol glycerol hydroxysteate, preferably polyethoxylated hydrogenated castor oil 40, or polyoxyl castor oil, preferably polyoxyl 35 castor oil, or macrogol glycerol hydroxysteate, also polyoxyl 15 hydroxysteate, or a mix of itself; while the MLT / PED mass ratio is 1: 1 (weight / weight); And c) 10 volume ethanol. |