| abstract |
A compound for use in the treatment of proliferative diabetic retinopathy in a patient in need thereof, wherein the compound has the structure of Formula (A): ** (See formula) ** wherein X is -C ( R9) 2-O- *, wherein the bond indicated with the asterisk is attached to the phenyl ring; Y is selected from: a) substituted or unsubstituted carbocyclyl, optionally substituted with C1-C4 alkyl, halogen, -OH or C1-C4 alkoxy; and b) C3-C10 substituted or unsubstituted alkyl, optionally substituted with halogen, -OH or C1-C4 alkoxy; R1 is hydrogen and R2 is hydroxyl; R7 is hydrogen; R8 is hydrogen or CH3; each R9 is independently hydrogen or substituted or unsubstituted C1-C4 alkyl; each R33 is independently selected from halogen or substituted or unsubstituted C1-C4 alkyl; and n is 0, 1 or 2; or tautomer, stereoisomer, geometric isomer, N-oxide or a pharmaceutically acceptable salt thereof. |