| abstract |
A compound comprising one of the formulas (Ic), (Id), (Ie), (IIa), (IIb), (IIc), (IIIa), (IIIb), (IIIc), (Va), (Vb ), (Vc), (Vd), (Ve), (Vf) or (Vg): ** (See formula) ** where each of P1, P2 and P3 is individually a protecting group or a hydrogen atom ; where is a double bond; where Z is -C (O) ORd, -C (O) NRcRc, -C (O) H, -C (NH) NRcRc, -C (S) H, -C (S) ORd, -C (S ) NRcRc or -CN; Each Ra is independently selected from hydrogen, (C1-C6) alkyl, (C3-C8) cycloalkyl, cyclohexyl, (C4-C11) cycloalkylalkyl, (C5-C10) aryl, phenyl, (C6-C16) aryl alkyl, 2-6 membered heteroalkyl, 3-8 membered cycloheteroalkyl, morpholinyl, piperazinyl, homopiperazinyl, piperidinyl, 4-11 membered cycloheteroalkylalkyl, 5-10 membered heteroaryl or 6-16 membered heteroarylalkyl; each Rc is independently a protecting group or Ra or, alternatively, each Rc is taken together with the nitrogen atom to which it is attached to form a 5- to 8-membered cycloheteroalkyl or heteroaryl that may optionally include one or more thereof or different additional heteroatoms and which may be optionally substituted with one or more of the same or different suitable Ra or Rb groups; each Rb is independently selected from = O, -ORd, halo (C1-C3) alkyloxy, -OCF3, = S, -SRd, = NRd, = NORd, - NRcRc, halogen, -CF3, -CN, -NC, -OCN , -SCN, -NO, -NO2, = N2, -N3, -S (O) Rd, -S (O) 2Rd, -S (O) 2ORd, -S (O) NRcRc, -S (O) 2NRcRc , -OS (O) Rd, -OS (O) 2Rd, -OS (O) 2ORd, -OS (O) 2NRcRc, -C (O) Rd, -C (O) ORd, -C (O) NRcRc, -C (NH) NRcRc, -C (NRa) NRcRc, -C (NOH) Ra, -C (NOH) NRcRc, -OC (O) Rd, -OC (O) ORd, -OC (O) NRcRc, - OC (NH) NRcRc, - OC (NRa) NRcRc, - [NHC (O)] nRd, - [NRaC (O)] nRd, - [NHC (O)] nORd, - [NRaC (O)] nORd, - [NHC (O)] nNRcRc, - [NRaC (O)] nNRcRc, - [NHC (NH)] nNRcRc or - [NRaC (NRa)] nNRcRc; R1, R2 and R3, if present, are each independently selected from (C1-C6) alkyl, (C3-C8) cycloalkyl, cyclohexyl, (C4-C11) cycloalkylalkyl, aryl ( C5-C10), phenyl, arylalkyl (C6-C16), benzyl, 2-6 membered heteroalkyl, 3-8 membered cycloheteroalkyl, morpholinyl, piperazinyl, homopiperazinyl, piperidinyl, 4-11 membered cycloheteroalkylalkyl, 5-10 heteroaryl membered or 6-16 membered heteroarylalkyl; each n is, independently, an integer from 0 to 3; and each Rd is, independently, a protecting group or Ra; or a pharmaceutically acceptable salt thereof. |