http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2791749-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5fbc0d876aba71e6d6e338ebf59451b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 |
| filingDate | 2014-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a72a4c970e82582287ee6153e98bf98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a990c748c915577ec5324e7990d0b48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc027c2c7f2aedff231d1d797d17ceba |
| publicationDate | 2020-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2791749-T3 |
| titleOfInvention | Halogenopyrazoles as thrombin inhibitors |
| abstract | A compound for use in treating a disease or disorder in a subject, the compound having Formula (IIa): **(See formula)** or a pharmaceutically acceptable salt, ester, solvate, or prodrug thereof; where L1 is -NR4-; L2 is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, -S-, -SO-, -SO2-, -O-, -NHSO2- or -NR4-; L3 is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, -S-, -SO-, -SO2-, -O-, -NHSO2- or -NR4-; R1 is substituted or unsubstituted C1-C24 alkyl, substituted or unsubstituted 2-20 membered heteroalkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted 4-8 membered heterocycloalkyl, substituted heterocycloalkenyl or unsubstituted, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; R2 is hydrogen, halogen, substituted or unsubstituted C1-C24 alkyl, substituted or unsubstituted 2-20 membered heteroalkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted 4-8 membered heterocycloalkyl substituted, substituted or unsubstituted heterocycloalkenyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is substituted or unsubstituted C1-C24 alkyl, substituted or unsubstituted 2-20 membered heteroalkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted 4-8 membered heterocycloalkyl, substituted heterocycloalkenyl or unsubstituted, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; R4 is hydrogen, substituted or unsubstituted C1-C24 alkyl, substituted or unsubstituted 2-20 membered heteroalkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 4-8 membered heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocycloalkenyl, or substituted or unsubstituted heteroaryl; and Y is fluorine, where any substituted L2, L3, R2 or R3 group may be substituted with one or more substituent groups selected from the following moieties: (A) -OH, -NH2, -SH, -CN, -CF3, -NO2, oxo, halogen, -COOH, unsubstituted C1-C24 alkyl, unsubstituted 2-20 membered heteroalkyl, unsubstituted C3-C8 cycloalkyl, unsubstituted 4-8 membered heterocycloalkyl, unsubstituted aryl, unsubstituted heteroaryl, and (B) C1-C24 alkyl, 2-20 membered heteroalkyl, C3-C8 cycloalkyl, 4-8 membered heterocycloalkyl, aryl, and heteroaryl, substituted with at least one substituent selected from: (i) oxo, -OH, -NH2, -SH, -CN, -CF3, -NO2, halogen, -COOH, unsubstituted C1-C24 alkyl, unsubstituted 2-20 membered heteroalkyl, unsubstituted C3-C8 cycloalkyl, unsubstituted 4-8 membered heterocycloalkyl substituted, unsubstituted aryl, unsubstituted heteroaryl, and (ii) C1-C24 alkyl, 2-20 membered heteroalkyl, C3-C8 cycloalkyl, heterocycloa 4- to 8-membered alkyl, aryl and heteroaryl, substituted with at least one substituent selected from: (a) oxo, -OH, -NH2, -SH, -CN, -CF3, -NO2, halogen, -COOH, alkyl unsubstituted C1-C24, unsubstituted 2-20 membered heteroalkyl, unsubstituted C3-C8 cycloalkyl, unsubstituted 4-8 membered heterocycloalkyl, unsubstituted aryl, unsubstituted heteroaryl, and (b) C1-C24 alkyl, unsubstituted heteroalkyl 2 to 20 membered, cycloalkyl, heterocycloalkyl from 4 to 8 members, aryl or heteroaryl, substituted with at least one substituent selected from: oxo, -OH, -NH2, -SH, -CN, -CF3, -NO2, halogen, -COOH, unsubstituted C1-C24 alkyl, unsubstituted 2-20 membered heteroalkyl, unsubstituted C3-C8 cycloalkyl, unsubstituted 4-8 membered heterocycloalkyl, unsubstituted aryl and unsubstituted heteroaryl; ... |
| priorityDate | 2013-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 328.