| abstract |
Recombinant CTLA-4 binding protein comprising: (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide bond connecting said CTLA-4 binding domain masking peptide to said CTLA-4 binding domain; wherein said CTLA-4 binding domain masking peptide comprises a sequence that exhibits or exhibits at least 90% identity with SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13 or SEQ ID NO: 14. |