http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2788999-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42a59c5faed1d0699d86edc5a2eee671 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-0222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-0238 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2005-3131 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24069 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M5-31513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M5-3129 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-315 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 |
| filingDate | 2015-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b00af74cca695493197e9029304636be |
| publicationDate | 2020-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2788999-T3 |
| titleOfInvention | Botulinum toxin prefilled container |
| abstract | A prefilled glass syringe comprising an aqueous formulation of botulinum toxin, the glass syringe comprising (a) a syringe barrel made of glass that includes a proximal end and a distal end, and a generally cylindrical wall extending between them and defining a lumen of the barrel, the barrel of the syringe has a distally projecting tip with a fluid path extending through it and communicating with the lumen of the barrel, wherein the generally cylindrical wall has an interior surface coated with a barrier layer, (b) a capping device having an outlet coupling portion that engages and seals and closes the distal open outlet end of the syringe, wherein the outlet coupling portion is made of an elastomeric material, and (c) a plunger rod assembly that extends toward the proximal end of the syringe barrel and includes a plugged plunger cap. sliding seal with the cylindrical wall of the cylinder lumen, wherein the plunger plug is made of an elastomeric material, which has a coating on at least a portion of the plunger plug that comes into contact with the aqueous formulation of botulinum toxin during storage and / or injection, where the barrier layer of the syringe barrel is a silicone layer, where the elastomeric material of the outlet coupling portion is selected from 2-mercaptobenzothiazole (MBT) free styrene-butadiene rubber and a mixture of isoprene rubber (IS) and bromine butyl rubber, wherein the elastomeric material of the plunger plug is a bromine butyl rubber, wherein the coating on the plunger plug is an ethylene-ethylene copolymer coating fluorinated, where the biological activity of the botulinum toxin expressed in Mouse Units (MU) is not reduced by more than 25%, in relation to the initial activity of the toxin, t After storage of the pre-filled syringe for 12 months at 5 ° C or 12 months at 25 ° C, and where the pH of the aqueous botulinum toxin formulation is between 6.1 and 7.3 during storage, and where The aqueous formulation of botulinum toxin comprises human albumin and sodium chloride. |
| priorityDate | 2014-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 108.