| abstract |
A compound of formula (I) ** (See formula) ** wherein R1 is cyclopropyl, alkyl or haloacetidinyl; R2 is cyclopropylmethoxy, alkoxy, haloalkoxy, halopyridinyl, alkylpyrazolyl, or halopyrrolidinyl; provided that at least one of R1 and R2 is cyclopropyl or cyclopropylmethoxy; R3 is -C (O) -NH-C (R4R5) -R6, -C (O) -R7 or R8; R4 and R5 are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkylsulfonylalkyl, and alkyloxetanyl; or R4 and R5 together with the carbon atom to which they are attached form oxethanyl or dioxothiethanyl; R6 is aminocarbonyl, 5-methyl-1,2,4-oxadiazol-3-yl, hydroxyalkyl, thiazolyl, alkoxycarbonyl, carboxy, difluoroacetidinylcarbonyl, 5-amino-1,2,4-oxadiazol-3-yl, alkylaminocarbonyl or aminocarbonylalkyl; R7 is (aminocarbonyl) (difluoro) pyrrolidinyl or (aminocarbonyl) azaspiro [2.4] heptyl; and R8 is 3-alkyl-1,2,4-oxadiazol-5-yl or 5-alkyl-1,2,4-oxadiazol-3-yl; or a pharmaceutically acceptable salt or ester thereof. |