| abstract |
A transdermal composition containing donepezil as an active ingredient, the transdermal composition comprising: (a) a support layer; (b) a drug-containing matrix layer comprising, based on the total weight of the drug-containing matrix layer, (b-1) 15-55% by weight of donepezil or a pharmaceutically acceptable salt thereof, (b -2) 25-70% by weight of an EVA-based adhesive, (b-3) 5-20% by weight of at least one selected from the group consisting of a pyrrolidone derivative and a C8-18 aliphatic derivative, and (b-4) 1-10% by weight of triacetin or a citric acid derivative, (c) a polymer adhesive matrix layer comprising, based on the total weight of the polymer adhesive matrix layer, 60% by weight or more of an acrylic adhesive, in which the acrylic adhesive does not contain a functional group; and (d) a release layer. |