| abstract |
A compound for use in a method of treatment, wherein the treatment is for a disease, disorder, symptom, or condition selected from acute pain, chronic pain, inflammatory pain, neuropathic pain, diabetic neuropathy, alcoholic polyneuropathy, cancer, or cancer- or chemotherapy-induced pain, a generalized pain disorder, tonic pain, persistent pain, postoperative pain, pain induced by a chemical agent, drug-induced pain, migraine, anxiety, musculoskeletal spasms, seizures, epilepsy, alcohol dependence and diseases associated with alcoholism, insomnia, pain associated with alcohol-induced hyperalgesia, type 1 and type 2 diabetes, diabetic complications, liver steatosis or liver cirrhosis, bipolar disorder, mania, sleep disorder, burning, post-traumatic stress disorder, heart disorder , inflammation and immune-mediated disorders (including microbial infection and organ transplantation), cancer (including breast, head and neck, prostate, and lung cancer), substance misuse, substance dependence, alcohol abuse, substance abuse, drug abuse, or related stimulant, sedative, hypnotic, or ataxic effects with drugs and a combination thereof, wherein the compound is selected from the group consisting of: ID Name IUPAC 901 N- [3- (azepan-1-yl) propyl] -1 - {[2- (4- chlorophenyl) -5-methyl-1,3-oxazol-4-yl] methyl} piperidine-4-carboxamide; 943 N- [3- (azepan-1-yl) propyl] -1 - ({5-methyl-2- [4- (trifluoromethyl) phenyl] -1,3-oxazol-4-yl} methyl) piperidin-4 -carboxamide; 945 N- [3- (azepan-1-yl) propyl] -1 - {[5-methyl-2- (pyridin-4-yl) -1,3-oxazol-4-yl] methyl} piperidin-4- carboxamide; 947 N- [3- (azepan-1-yl) propyl] -1 - {[2- (2,4-difluorophenyl) -5-methyl-1,3-oxazol-4-yl] methyl} piperidin-4- carboxamide; 949 N- [3- (azepan-1-yl) propyl] -1 - {[2- (1,3-benzodioxol-5-yl) -5-methyl-1,3-oxazol-4-yl] methyl} piperidine-4-carboxamide; 951 N- [3- (azepan-1-yl) propyl] -1 - {[2- (2,4-dimethoxyphenyl) -5-methyl-1,3-oxazol-4-yl] methyl} piperidin-4- carboxamide; 953 N- [3- (azepan-1-yl) propyl] -1 - {[2- (4-benzylphenyl) -5-methyl-1,3-oxazol-4-yl] methyl} piperidine-4-carboxamide; 955 N- [3- (azepan-1-yl) propyl] -1 - ({2- [4- (dimethylcarbamoyl) phenyl] -5-methyl-1,3-oxazol-4-yl} methyl) piperidin-4 - carboxamide; 957 N- [3- (azepan-1-yl) propyl] -1 - ({5-methyl-2- [4- (piperidin-1-yl) phenyl] -1,3-oxazol-4-yl} methyl ) piperidine-4-carboxamide; and 959 N- [3- (azepan-1-yl) propyl] -1 - {[5-methyl-2- (naphthalen-1-yl) -1,3-oxazol-4-yl] methyl} piperidin-4 -carboxamide; or a salt or a solvate thereof. |