| abstract |
A controlled release pharmaceutical formulation, comprising cyclosporin-loaded microparticles of a bioresorbable polymer, comprising poly (D, L-lactide), wherein the average diameter of the microparticles is in the range of 20 µm to 40 µm, and wherein the formulation comprises said microparticles suspended in a liquid vehicle, a liquid vehicle having a viscosity between 30 and 45 mPas as measured at 20 ° C using an A&D SV-1a vibro viscometer (A&D Instruments Ltd) according to the instructions of the manufacturer, and where the formulation comprises a thixotropic agent selected from the group consisting of: hypromellose, hydroxyethyl cellulose, hydrophilically modified hydroxyethyl cellulose, xanthan gum, guar gum and cetyl alcohol, and where the liquid formulation exhibits a thinning behavior by shear so that the viscosity decreases under shear stress. |