| abstract |
A sulfonamide derivative represented by the following general formula (1) or one of its pharmaceutically acceptable salts: ** (See formula) ** where A represents a group represented by the following general formula (2-1), (2- 2), (2-3) or (2-4): ** (See formula) ** where Arm is a cyclic alkyl group or an aromatic ring containing 0, 1, 2, 3 or 4 heteroatoms selected from atoms of oxygen, sulfur atoms and nitrogen atoms, R1, R11, R21, R51, and R52 each independently represent any one of a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group , a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a lower hydroxyalkyl group, a lower hydroxyalkenyl group, a lower hydroxyalkoxy group, a lower haloalkyl group, a lower haloalkoxy group, a lower haloalkylthio group, a lower haloalkenyl group , a nitro group, ag cyano group, an amino group, a lower alkylamino group, a (lower alkylamino) - (lower alkyl) group, a carboxyl group, a (lower alkyloxy) -carbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group and an ammonium group, R12, R13 and R14 each independently represent any one of a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a lower hydroxyalkyl group, a lower hydroxyalkenyl group, a lower hydroxyalkoxy group, a lower haloalkyl group, a lower haloalkoxy group, a lower haloalkylthio group, a lower haloalkenyl group, a nitro group, a cyano group, an amino group, a lower alkylamino group, a (lower alkoxy) - (lower alkylene) group, a (lower alkylthio) - (alkali lower leno), a (lower alkylamino) - (lower alkylene) group, a (lower alkylamino) - (lower alkyl) group, a carboxyl group, a (lower alkyloxy) -carbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group, and an ammonium group, and R2, R3, R22, R23, R24, R25, and R53 each independently represent any one of a hydrogen atom, a halogen atom, a group hydroxyl, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a lower hydroxyalkyl group, a lower hydroxyalkenyl group, a lower hydroxyalkoxy group, a lower haloalkyl group, a haloalkoxy group lower, a lower haloalkylthio group, a lower haloalkenyl group, a nitro group, a cyano group, an amino group, a lower alkylamino group, a (lower alkylamino) - (lower alkyl) group, a carboxyl group, a (lower alkyloxy) -carbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group and an ammonium group, ... |