http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2777205-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a7f3068c412965d1d753bd152f94fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60462c2fbaa4b0df64bc7ca35d70e217 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_917ed402f5a566bd20071da725a33560 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56961 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 |
| filingDate | 2013-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b697cf652a4a10bafc89ed7b839c2bd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4d50663e1c10a8eca6651ed208ec84f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ffa9ebabc26dea3d7e6b203c72b95ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a0b9496829164b2a8b3970f725bc96d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53597e4b13c536b6f9107b7b0e3fab14 |
| publicationDate | 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2777205-T3 |
| titleOfInvention | Procedure for the diagnosis of invasive Candida infections |
| abstract | An in vitro method for diagnosing invasive candidiasis (IC) in a subject, said method comprising: a) detecting the level of a Candida glycan which is a mannan in a blood, plasma or serum sample from the subject; b) detect the level of antibodies directed against a Candida protein selected from the group consisting of fructose bisphosphate aldolase (Fba1), enolase 1 (Eno1), heat shock protein 90 (Hsp90), hypha wall protein (Hwp1) and mannoprotein 65 (Mp65) in the same blood, plasma, or serum sample from the subject or in another blood, plasma, or serum sample obtained sequentially from the same patient, essentially simultaneously or no more than 3 hours apart; and c) where a combined analysis is performed of the level of said Candida glycan and the level of antibody directed against said Candida protein selected from the group consisting of Fba1, Eno1, Hsp90, Hwp1 and Mp65, calculating the level of a virtual marker Z = Σ ai x [Marcadori], where [Marcadori] are individual levels of Candida glycan marker and antibody directed against said Candida protein selected from the group consisting of Fba1, Eno1, Hsp90, Hwp1 and Mp65, and ai are coefficients whose values are determined to maximize the area under the curve (AUC) of the relative operating characteristic curve (ROC) for the Marcadori combination; and d) where if the level of the virtual marker Z calculated in step c) is higher than a reference level of the virtual marker Z, then the subject is developing or has developed invasive candidiasis. |
| priorityDate | 2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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