http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2774975-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ffd5528fd07384d7b07ab484ed5b143 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-46 |
| filingDate | 2015-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86146b0bc371459f4a2e9f0e0e79b87b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c55d0ef58aec0d18e1c5d016025bf31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c7fa9de8b742c98619cf121d94b391d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9131374855ec78d53b111deaa0dab41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ceeb68341c614baf8e1d98a0a4ae1e56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_666872b84e85beacffca50ee4a7ae4d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4888e57a762952a0d4b8a143f8dbf237 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69810734f6700b95580f35600d42b826 |
| publicationDate | 2020-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2774975-T3 |
| titleOfInvention | Hsp70 modulators and methods of making and using it |
| abstract | A compound of formula I: ** (See formula) ** or a pharmaceutically acceptable salt thereof, where: X is -N = or -CH =; X1 is -N = or -C (R5) =; ** (See formula) ** R1a is ** (See formula) ** or C1-6 straight chain aliphatic optionally substituted with one or more groups independently selected from -OH or member heteroaryl having 1-2 independently selected heteroatoms between nitrogen, oxygen or sulfur; each R1b is independently hydrogen, C1-4 alkyl, or two R1b groups are optionally taken together to form an oxo group; each of R1c and R1d is independently hydrogen or C1-4 alkyl; R2 is -O-CH2-Ring A, -NH-CH2-Ring A, or -O-CH2CH2-Ring A; ** (See formula) ** Ring A is unsubstituted phenyl, unsubstituted pyridinyl furanyl optionally substituted with RA5; each of RA1 is independently halogen, -CN, -C (O) N (R) 2, -N (R) 2, -OR, -C (O) R, -N3, a heterocyclyl or heteroaryl of 5 or 6 optionally substituted members having one or two heteroatoms independently selected from nitrogen, oxygen or sulfur, or C1-4 alkyl optionally substituted with one or more halogen atoms; each R is independently hydrogen or C1-4 alkyl optionally substituted with one or more halogen atoms; RA2 is -Cl, -Br, -I, -CN, -C (O) N (R) 2, -N (R) 2, -OR, -C (O) R, -N3, C1-4 alkyl syn branching in the benzylic position and optionally substituted with one or more halogen atoms, or an optionally substituted 5- or 6-membered heterocyclyl or heteroaryl having one or two heteroatoms independently selected from nitrogen, oxygen, or sulfur; n is 1 to 4; RA3 is -H or -F; RA4 is -F or -OR; RA5 is -OR or -N (R) 2; R3 is -C (O) N (R3a) 2, -OR3b, -C (O) H, -C (O) OR, or -N (R3c) 2; each R3a is independently hydrogen or C1 alkyl optionally substituted with one or more groups independently selected from halogen or 1-pyrrolidinyl; R3b is hydrogen or C1-4 alkyl optionally substituted with one or more groups independently selected from halogen, C1-4 alkyl, C1-4 haloalkyl, oxo, or -N (R) 2; each R3c is independently hydrogen or C1-4 alkyl optionally substituted with one or more groups independently selected from halogen, C1-4 alkyl, C1-4 haloalkyl, oxo, or -N (R) 2; R4 is R or halogen; and R5 is hydrogen, methyl, or -N (R) 2; where the term "alkyl" includes saturated aliphatic groups, including straight chain alkyl groups, branched chain alkyl group, cycloalkyl (alicyclic) groups, alkyl substituted cycloalkyl groups, and cycloalkyl substituted alkyl groups. |
| priorityDate | 2014-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 915.