| abstract |
A pharmaceutical composition comprising a conjugate and a pharmaceutically acceptable carrier, adjuvant, diluent, preservative and / or solubilizer, wherein the conjugate comprises the reaction product of an activated polyalkylene glycol polymer and B, wherein B is a beta interferon ( IFN β); and said activated polyalkylene glycol polymer is 20 kDa mPEG-O-2-methylpropionaldehyde, 20 kDa mPEG-Op-methylphenyl-O-2-methylpropionaldehyde, 20 kDa mPEG-Om-methylphenyl-O-2-methylpropionaldehyde, mPEG- 20 kDa O-pphenylacetaldehyde, 20 kDa mPEG-Op-phenylpropionaldehyde or 20 kDa mPEG-Om-phenylacetaldehyde. |