http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2774662-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4733b7f3cb9bd7f59085e42c2280ee47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5153 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-0093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-282 |
| filingDate | 2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06e77862c67da80adc32cb0af984cfc3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42a53ed17d6f1c42350aa14a4f1bb4c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b58310b4493121a264e752a7081fd6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63cff519919440c4ec965fc1274d635b |
| publicationDate | 2020-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2774662-T3 |
| titleOfInvention | Pt (IV) derivatives and nanotransporters that comprise them |
| abstract | A compound of formula (I), or a salt form thereof, ** (See formula) ** wherein Pt is a platinum atom; A is a C8-C22 fatty acid associated with the Pt atom via an oxygen atom of the fatty acid; B is a C2-C7 fatty acid associated with the Pt atom via an oxygen atom of the fatty acid; Provided that each of A and B is not C6-C9 branched alkyl fatty acid; L is a ligand atom or group of atoms selected from alkyl containing 1 to 20 carbons, alkenyl containing 2 to 20 carbons, alkynyl containing 2 to 20 carbons, cycloalkyl containing 3 to 10 carbon atoms, cycloalkenyl containing 3 to 10 carbon atoms, cycloalkynyl containing 3 to 10 carbon atoms, aryl containing 6 to 10 carbon atoms, heteroaryl containing 5 to 15 members where 1 to 3 of the atoms in the system ring are a heteroatom selected from nitrogen, oxygen or sulfur, heterocyclyl containing 3 to 10 members wherein 1 to 3 of the atoms in the ring system are a heteroatom selected from nitrogen, oxygen or sulfur, halide atom, -NR1R2, -OR3, -SR4, -S (O) R5, C2-C20 alkylene-COOH, -OH, -SH, -NH, or any of the ligands L1 to L5 as designated herein; and n is the number of ligand residues, being 1, 2, 3 or 4; R1 and R2 are each independently selected from hydrogen, alkyl containing 1 to 20 carbons, alkenyl containing 2 to 20 carbons, cycloalkyl containing 3 to 10 carbon atoms, cycloalkenyl containing 3 to 10 atoms carbon, cycloalkynyl containing 3 to 10 carbon atoms, aryl containing 6 to 10 carbon atoms, heteroaryl comprising 5 to 15 members where 1 to 3 of the atoms in the ring system are a heteroatom selected from nitrogen , oxygen or sulfur, heterocyclyl containing 3 to 10 members where 1 to 3 of the atoms in the ring system are a heteroatom selected from nitrogen, oxygen or sulfur, halide, -C (O) NR6R7, sulfinyl, ester and carbonyl ; or wherein R1 and R2 form a cyclic structure with the N atom being attached to; each of R3, R4 and R5 is independently selected from hydrogen, alkyl containing 1 to 20 carbons, alkenyl containing 2 to 20 carbons, alkynyl containing 2 to 20 carbons, cycloalkyl containing 3 to 10 carbon atoms carbon, cycloalkenyl containing 3 to 10 carbon atoms, cycloalkynyl containing 3 to 10 carbon atoms, aryl containing 6 to 10 carbon atoms, heteroaryl containing 5 to 15 members where 1 to 3 of the atoms in the ring system are a heteroatom selected from nitrogen, oxygen or sulfur, heterocyclyl containing 3 to 10 members where 1 to 3 of the atoms in the ring system are a heteroatom selected from nitrogen, oxygen or sulfur, halide, sulfinyl, ester and carbonyl; and R6 and R7 are each independently selected from hydrogen, alkyl containing 1 to 20 carbons, alkenyl containing 2 to 20 carbons, cycloalkyl containing 3 to 10 carbon atoms, cycloalkenyl containing 3 to 10 carbon atoms carbon, cycloalkynyl containing 3 to 10 carbon atoms, aryl containing 6 to 10 carbon atoms, heteroaryl comprising 5 to 15 members where 1 to 3 of the atoms in the ring system are a heteroatom selected from nitrogen, oxygen or sulfur, heterocyclyl containing 3 to 10 members where 1 to 3 of the atoms in the ring system are a heteroatom selected from nitrogen, oxygen or sulfur, halide, sulfinyl, ester, carbonyl, -OH, -SH and - NH, where at least one of the following conditions is met: (i) at least one ligand L is attached to the platinum atom via at least one heteroatom selected from nitrogen, oxygen, and sulfur; (ii) the platinum atom is associated with one or more C8-C22 fatty acid groups, provided that said fatty acid is not a C6-C9 branched alkyl fatty acid; (iii) the platinum atom is associated with one or more C8-C22 fatty acid groups, the compound having a logP value of between approximately 2 and 9 in an octanol / water mixture, provided that said fatty acid is not a fatty acid C6-C9 branched alkyl. |
| priorityDate | 2014-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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