http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2771251-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5094 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56972 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17 |
| filingDate | 2013-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b00d81c176d2d9af73a6cbfd460ccf69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0482edd79db39c2231623ac33613310b |
| publicationDate | 2020-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2771251-T3 |
| titleOfInvention | Methods of producing enriched populations of tumor-reactive T cells from peripheral blood |
| abstract | Method of obtaining a population of cells enriched in tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of peripheral blood mononuclear cells (PBMC) from a peripheral blood sample, (b) selecting specifically CD8 + T cells that also express PD-1 (programmed cell death protein 1) and / or TIM-3 (domain 3 of mucin and T cell immunoglobulin) from the bulk population, and (c) separate the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells; optionally wherein the method further comprises: (i) culturing the enriched cell population obtained in (c) in the presence of any one or more of TWS119 (3 - [[6- (3-aminophenyl) -7H-pyrrolo [2 , 3-d] pyrimidin-4-yl] oxy] phenol), interleukin (IL-21), IL-12, IL-15, IL-7, transforming growth factor (TGF) beta, and AKT inhibitor (AKTi) , (ii) stimulate the enriched cell population obtained in (c) with a tumor antigen and / or with autologous tumor T cells, and / or (iii) transduce or transfect the cells of the enriched population obtained in (c) with a nucleotide sequence encoding any one or more of IL-12, IL-7, IL-15, IL-2, IL-21, mir155, and anti-PD-1 siRNA. |
| priorityDate | 2013-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 126.