| abstract |
A compound of Formula I wherein: ** (See formula) ** R1 is azetidinyl, imidazolyl, pyrimidinyl, triazolyl, tetrahydropyranyl, thiazolyl, pyridyl, piperidinyl, phenyl, oxazolyl, or isoxazolyl; wherein said piperidinyl, pyridyl, imidazolyl and phenyl are optionally substituted with SO2CH3, C (O) CH3, CH3, CF3, Cl, F, -CN, OCH3 or N (CH3) 2; and optionally substituted with 1 to one additional group independently selected from Cl, OCH3 and CH3; and wherein said triazolyl, oxazolyl, isoxazolyl, and thiazolyl are optionally substituted with one or two CH3 groups; and wherein said azetidinyl is optionally substituted with CO2C (CH3) 3 or C (O) CH3; R2 is C (1-6) alkyl, cyclopropyl or C (2-4) alkynyl; R3 is OH; R4 is H; R5 is Cl, -CN, CF3, CH3, OH, N (CH3) OCH3, N (CH3) 2, azetidin-1-yl, or OCH3; R6 is pyridyl or phenyl, wherein said phenyl is optionally substituted with Cl, F, CF3, SO2CH3, or OCF3; or R6 is -O-phenyl, wherein said -O-phenyl is optionally substituted with Cl, F, or -CN; or R6 is -CH2R6 ', where R6' is pyridyl, or phenyl, wherein said pyridyl or phenyl is optionally substituted with pyrazol-1-yl, 1,2,4-triazol-1-yl, CF3, OCH3, SO2CH3 , Cl, F, or -CN; R7 is Cl, -CN, C (1-4) alkyl, OC (1-2) alkyl or NA1A2; A1 is C (1-2) alkyl; A2 is C (1-2) alkyl, CH2CH2OCH3 or OCH3; or A1 and A2 can be taken together with their attached nitrogen to form a ring selected from the group consisting of: ** (See formula) ** Ra is OH, OCH3, F; R8 is H; R9 is H; and pharmaceutically acceptable salts thereof. |