http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2770050-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a05d260411db5deaad8fc25a410f691 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-14 |
| filingDate | 2015-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d143be2fb7791f809fa6e58ce1d5150 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46e0270a2ec8391d4f166d94402c6abd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a16f1b6d2136628528478adde9c58b52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1209bb50b3fc82f5b009fdb32c53d129 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f43113396675765c7729746e24e2a56d |
| publicationDate | 2020-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2770050-T3 |
| titleOfInvention | New procedure for the preparation of dolutegravir and its pharmaceutically acceptable salts |
| abstract | A method for preparing dolutegravir of formula I, ** (See formula) ** comprising: a) reacting the compound of formula II or a reactive derivative thereof with 2,4-difluorobenzylamine to provide a compound of formula III ** (See formula) ** where R is an alkyl, aryl or aralkyl group, P1 and P2 independently represent a ketal protecting group, or together form a cyclic ring; b) deprotecting the compound of formula III to provide a compound of formula IV; ** (See formula) ** c) converting the compound of formula IV into a compound of formula V; ** (See formula) ** d) reacting the compound of formula V with a compound of formula VI to provide a compound of formula VII ** (See formula) ** wherein R1 and R2 independently represent an alkyl; e) condensing the compound of formula VII with a compound of formula VIII to provide a compound of formula IX ** (See formula) ** wherein R3 and R4 are independently alkyl, aryl or aralkyl; f) converting the compound of formula IX to a compound of formula X; ** (See formula) ** g) reacting the compound of formula X with (R) -3-amino-1-butanol to provide a compound of formula XI; and ** (See formula) ** h) converting the compound of formula XI into dolutegravir of formula I. |
| priorityDate | 2014-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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