http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2768996-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a7ac31dafa9b644bcbf73f79c4695dc |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate | 2015-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a00ffeb6bfef65dba46c0f3291d0186 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61ebcaab6f43c1fd0405d8d346f33ee1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c05c8715e4c048525655f87e4c05ce26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60b3f41773a4800ebab11c7dac5a4be2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b97ac0bd6b1904a15402bdb98b076ab0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01ba81fc9465f95f03c7c9ef7e9a769e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e06514bdbf7e4214a5c3ce22f43d33a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a120404bc9cb5c265a71c6ff1bc4332 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5da6ec93f510bc7b714db3839b6dec48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6c88a08584f4f1d2ef994faacc33959 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ad86d0b02d6281589af907f55bc49b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a41c1a8affb57c50ca1aa659a5a29d2 |
| publicationDate | 2020-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2768996-T3 |
| titleOfInvention | Pyrrolopyrimidines and pyrazolopyrimidines used as inhibitors of ubiquitin-specific protease 7 |
| abstract | A compound having the Formula (Ig) or (Ih): ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein: R2 is (C1-C8) alkyl, aryl, heteroaryl, (C3-C8 ) cycloalkyl, heterocyclyl, -NR10R11 or -OR10, wherein alkyl, aryl, cycloalkyl and heterocyclyl are optionally substituted with one or more R8; R4 is (C1-C6) alkyl, - (C0-C3) alkylene-aryl, heteroaryl, (C3-C8) cycloalkyl, CD3, or heterocyclyl, where aryl, heteroaryl, heterocyclyl, and cycloalkyl are optionally substituted with one or more R12 ; each R8 is independently at each occurrence selected from D, (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, - (C1-C3) -alkylene-O ( C1-C6) alkyl, - (C0-C4) -alkylene-aryl, - (C0-C4) -alkylene-heteroaryl, (C3-C10) cycloalkyl, heterocyclyl, - (C0-C4) -alkylene-O-aryl, - (C0-C4) -alkylene-O-heteroaryl, -O- (C3-C8) cycloalkyl, -S-heteroaryl, halogen, -CN, -C (O) R10, -CO (O) R10, -C ( O) NR10R11, -S (O) qR10, -S (O) qNR10R11, -NR10S (O) qR11, - (C0-C3) -alkylene-NR10R11, -NR10C (O) R11, -NR10C (O) C ( O) R11, -NR10C (O) NR10R11, -P (O) ((C1-C6) alkyl) 2, -P (O) (aryl) 2, -SiMe3SF5 or -OH, where alkyl, alkylene, aryl, heteroaryl, and heterocyclyl are optionally substituted with one or more R9; or two R8 together when on adjacent carbons form an aryl ring optionally substituted with one or more R9; or two R8 together when on adjacent carbons form a heteroaryl ring optionally substituted with one or more R9; or two R8 together when on adjacent carbons form a heterocyclyl ring optionally substituted with one or more R9; each R9 is independently in each case selected from D, (C1-C6) alkyl, (C1-C6) alkoxy, (C3-C8) cycloalkyl, halogen, aryl, -OH, -CN, -C (O) R10, - C (O) NR10R11, -NR10C (O) R11, -NR10R11, -S (O) qR10, -S (O) qNR10R11, -NR10S (O) qR11, oxo, -P (O) ((C1-C6) alkyl) 2, -P (O) (aryl) 2, -SiMe3SF5 -O-aryl, CN, or -O-heteroaryl, wherein alkyl, aryl, and cycloalkyl are optionally substituted with one or more substituents independently selected from (C1- C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, halogen, aryl, -NR14C (O) R15 -NR14S (O) qR15, -OH or -CN; or two R9 together when on adjacent carbons form an aryl ring; or two R9 together when on adjacent carbons form a heteroaryl ring; or two R9 together when on adjacent carbons form a (C3-C10) cycloalkyl ring; each R10 and R11 is independently at each occurrence selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, - (C0-C3) alkylene-aryl, - (C0-C4) alkylene- (C3-C8) cycloalkyl, - (C0-C4) alkylene-heterocyclyl, - (C0-C4) alkylene-heteroaryl, or -CN, where alkyl, alkenyl, alkynyl, alkylene, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more substituents independently selected from (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, (C3-C8) cycloalkyl, heterocyclyl, aryl, -S (O) q (C1-C3) alkyl, -S (O) qNR14R15, -NR14R15, -NR14C (O) R15 halogen, -OH or -CN; or R10 and R11 together form a heterocyclyl ring optionally substituted with one or more substituents selected from oxo, -C (O) (C1-C3) alkyl or -CNR14NR15; each R12 is independently at each occurrence selected from D, (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C3-C8) cycloalkyl, aryl, heteroaryl, -O-aryl, -O -heteroaryl, -O-heterocyclyl, -O- (C3-C8) cycloalkyl, -S (O) qR10, - (CH2) pC (O) OR10, -C (O) NR14R15, -S (O) qNR14R15, - NR14R15, -NR14C (O) NR14R15, - NR14C (O) OR10, -NR14SOqR10, -NR14COR10, halogen, -P (O) ((C1-C6) alkyl) 2, -P (O) (aryl) 2, - SiMe3SF5 or -OH, where alkyl, aryl, heteroaryl, and cycloalkyl are optionally substituted with one or more R13; each R13 is independently at each occurrence selected from D, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) alkoxy, halogen, (C1-C6) alkyl haloalkoxy, (C1-C6) hydroxyalkyl, heterocyclyl , heteroaryl, aryl, -OR14, -C (O) R14, -C (O) NR14R15, -NR14R15, -S (O) qR14, -NR14S (O) qR15, -S (O) qNR14R15, -NR14C (O ) NR14R15, -NR14C (O) OR15 -P (O) ((C1-C6) alkyl) 2, -P (O) (aryl) 2, -SiMe3SF5 or -CN, where alkyl, cycloalkyl, aryl, heterocyclyl and heteroaryl are substituted with one or more substituents independently selected from (C1-C6) alkyl, -NR14C (O) R15 -OH, -CN, -C (O) R14 or -CNR14R15; or two R13 together when on adjacent carbons form a heterocyclyl ring optionally substituted with one or more R16; or two R13 together when on adjacent carbons form a heteroaryl ring optionally substituted with one or more R16; or two R13 together with the carbon to which they are attached may form a spiroheterocyclyl optionally substituted with one or more R16; each R14 and R15 are independently at each occurrence selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, - (C1-C4) alkylene- (C3-C8) cycloalkyl, - (C0-C4) alkylene-heterocyclyl, - (C0-C4) alkylene-aryl, - (C0-C4) alkylene-heteroaryl, or -CN, where alkyl, alkenyl, alkynyl, alkylene, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more R16; or R14 and R15 together form a heterocyclyl ring optionally substituted with one or more R16; each R16 is independently at each occurrence selected from D, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C1-C6) haloalkyl, (C1-C6) alkoxy, (C1-C6) ) haloalkoxy, -C (O) (C1-C3) alkyl, -NHC (O) (C1-C4) alkyl, -CN, -CH2CN, oxo, -S (O) q (C1-C6) alkyl, or - OH; or two R16 together when on adjacent carbons form an aryl ring; or two R16 together when on adjacent carbons form a spiroheterocyclyl ring; p is 0, 1 or 2; and each q is 0, 1 or 2; where aryl is phenyl, biphenyl, naphthyl, anthracenyl, phenylenyl, phenanthrenyl, indanyl, indenyl, tetrahydronaphthalenyl, or tetrahydrobenzoanylenyl; Heteroaryl is a monovalent monocyclic aromatic radical with 5 to 24 ring atoms or a polycyclic aromatic radical, containing one or more ring heteroatoms selected from N, O or S, the remaining ring atoms being C, where when a heteroaryl group contains two fused rings, the fused rings can optionally be a saturated or partially saturated ring fused with a fully unsaturated ring; cyclocycloalkyloxylalcoa, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, oxazolinyl, oxazolidinyl, thiazolinyl, thiazolidinyl, thiozolidinyl, pyranyl, thiopyranyl, tetrahydropyranyl, dioxalinyl, pyperidinyl, thiomorpholinyl-oxazolidinyl, thiomorpholynyl, piperazomorpholinyl, oxideepolinyl, thiomorpholinyl, piperazomorpholinyl tropanil, oxazolidinonyl, and homotropanil; and spiroheterocyclyl is a spirocycle wherein at least one of the rings is a heterocycle. |
| priorityDate | 2014-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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