http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2766498-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a7233fdbf9dd37fc3a8426b3f6b7d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b25d8e6a9f37898073bf9e6f065b5b9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 |
| filingDate | 2016-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a64cd9b17aa388bdb606a91a8827452 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2ffee6059a72f78247a6ba84de7aabc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b663710beb265f458733b5c575a3093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_164f3d81d328fb341d3df6dd224c20ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46cc9341cb9a6142b29642be39aca09f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_571ca31abb4174b803734a2e8c82de70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93ce2a0313f94f85d8151abefe35eade http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97589a5c03d66b788cdc4509505c7c04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_976549f0ba9629314d73ee370aeaa622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a1404f643e101dc6f249260128ccc06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4318137c76af700397f7d91e20b1b044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1a4f261fabd450ec6e83423a0002b8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4deb2b72d45c7c4e65c4becb61c4397d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1d6f178e116889b15b771b4bfd810ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b54aa72c65b61b339969b38cbdfdd8a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5203393d7be10913e0a02457562b76e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc1d3d955e6c2ee7377f0c12fdd75f57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6d7c41a9a96c5c7d4b16d9cbd75cf72 |
| publicationDate | 2020-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2766498-T3 |
| titleOfInvention | Certain protein kinase inhibitor |
| abstract | A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: Q is selected from heteroaryl; W is selected from N and CR6; Z is selected from N and CR6; R1 is selected from heterocyclyl and heterocyclyl-C1-4alkyl, wherein alkyl and heterocyclyl are each unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from RX; each R2 is independently selected from hydrogen, halogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, heterocyclyl, heterocyclyl-C1-4 alkyl, aryl , aryl-C1-4alkyl, heteroaryl, heteroaryl-C1-4alkyl, -NO2, -NRA1RB1, -ORA1, -SRA1, -S (O) rRA1, -S (O) 2ORA1, -OS (O) 2RB1, -S (O) rNRA1RB1, -P (O) RA1RB1, -P (O) (ORA1) (ORB1), - (CRC1RD1) tNRA1RB1, - (CRC1RD1) tORB1, - (CRC1RD1) tSRB1, - (CRC1RD1) tS O) rRB1, - (CRC1RD1) tP (O) RA1RB1, - (CRC1RD1) tP (O) (ORA1) (ORB1), - (CRC1RD1) tCO2RB1, - (CRC1RD1) tC (O) NRA1RB1, - (CRC1RD1) (O) RB1, - (CRC1RD1) tNRA1CO2RB1, - (CRC1RD1) tOC (O) NRA1RB1, - (CRC1RD1) tNRA1CONRA1RB1, - (CRC1RD1) tNRA1SON2NRA1RC1 -NRB1, tOC (O) NRA1RB1, - (CRC1RD1) tNRA1CONRA1RB1, - (CRC1RD1) tNRA1SON2NRA1RC1 -NRB1, tRB1 (CRC1RD1) (CRC1RB1) ) tNRA1RB1, - S (O) r (CRC1RD1) tNRA1RB1, -C (O) RA1, -C (O) (CRC1RD1) tNRA1RB1, -C (O) (CRC1RD1) tORB1, -C (O) (CRC1RD1) tSRB1 , - C (O) (CRC1RD1) tS (O) rRB1, -CO2RB1, -CO2 (CRC1RD1) tC (O) NRA1RB1, -OC (O) RA1, -CN, -C (O) NRA1RB1, -NRA1C (O ) RB1, - NRA1CO2RB1, -OC (O) NRA1RB1, -NRA1C (O) NRA1RB 1, -NRA1S (O) rRB1, -CRA1 (= N-ORB1), -C (= NRE1) RA1, - C (= NRE1) NRA1RB1, -NRA1C (= NRE1) NRA1RB1, -CHF2, -CF3, -OCHF2 , and -OCF3, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from RX; Each R3 is independently selected from hydrogen, halogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, heterocyclyl, heterocyclyl-C1-4 alkyl, aryl , aryl-C 1-4 alkyl, heteroaryl, heteroaryl-C 1-4 alkyl, -NO2, -NRA2RB2, -ORA2, -SRA2, -S (O) rRA2, -S (O) 2ORA2, -OS (O) 2RB2, -S (O) rNRA2RB2, -P (O) RA2RB2, -P (O) (ORA2) (ORB2), - (CRC2RD2) tNRA2RB2, - (CRC2RD2) tORB2, - (CRC2RD2) tSRB2, - (CRC2RD2) tS O) rRB2, - (CRC2RD2) tP (O) RA2RB2, - (CRC2RD2) tP (O) (ORA2) (ORB2), - (CRC2RD2) tCO2RB2, - (CRC2RD2) tC (O) NRA2RB2, - (CRC2RD2) (O) RB2, - (CRC2RD2) tNRA2CO2RB2, - (CRC2RD2) tOC (O) NRA2RB2, - (CRC2RD2) tNRA2CONRA2RB2, - 30 (CRC2RD2) tNRA2SO2NRA2RB2, -NRA2RB2 (CRC2RB2, -NRA2) (CRC2RB2, -NRA2) (CRC2RD2) tNRA2RB2, - S (O) r (CRC2RD2) tNRA2RB2, -C (O) RA2, -C (O) (CRC2RD2) tNRA2RB2, -C (O) (CRC2RD2) tORB2, -C (O) (CRC2RD2 ) tSRB2, - C (O) (CRC2RD2) tS (O) rRB2, -CO2RB2, -CO2 (CRC2RD2) tC (O) NRA2RB2, -OC (O) RA2, -CN, -C (O) NRA2RB2, -NRA2C (O) RB2, - NRA2CO2RB2, -OC (O) NRA2RB2, -NRA2C (O) NR A2RB2, -NRA2S (O) rRB2, -CRA2 (= N-ORB2), -C (= NRE2) RA2, - C (= NRE2) NRA2RB2, -NRA2C (= NRE2) NRA2RB2, -CHF2, -CF3, -OCHF2 , and -OCF3, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from RX; or two R3 together with the carbon atoms to which they are attached form a 3- to 7-membered cyclic ring containing 0, 1, or 2 additional heteroatoms independently selected from oxygen, sulfur, and nitrogen, and optionally substituted with 1, 2, or 3 RX groups; R4 is selected from hydrogen, halogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, heterocyclyl, heterocyclyl-C1-4 alkyl, aryl, aryl -C 1-4 alkyl, heteroaryl, heteroarylC 1-4 alkyl, -NO2, - NRA3RB3, -ORA3, -SRA3, -S (O) rRA3, -S (O) 2ORA3, -OS (O) 2RB3, -S (O) rNRA3RB3, -P (O) RA3RB3, -P (O) (ORA3) (ORB3), - (CRC3RD3) tNRA3RB3, - (CRC3RD3) tORB3, - (CRC3RD3) tSRB3, - (CRC3RD3) tS (O) rRB3, - (CRC3RD3) tP (O) RA3RB3, - (CRC3RD3) tP (O) (ORA3) (ORB3), - (CRC3RD3) tCO2RB3, - (CRC3RD3) tC (O) NRÅ3RB3, - (CRC3RD3) (CRC3RD3) ) RB3, - (CRC3RD3) tNRA3CO2RB3, - (CRC3RD3) tOC (O) NRA3RB3, - (CRC3RD3) tNRA3CONRA3RB3, - (CRC3RD3) tNRA3SO2NRA3RB3, - NRA3-CRC3RB3, - CRC3RNRA3 (CRC3RB3) -NRA3-CRC3RB3, - CRC3RNR3 (CRC3RB3) tNRA3RB3, -S (O) r (CRC3RD3) tNRA3RB3, -C (O) RA3, - C (O) (CRC3RD3) tNRA3RB3, -C (O) (CRC3RD3) tORB3, -C (O) (CRC3RD3) tSRB3, -C (O) (CRC3RD3) tS (O) rRB3, -CO2RB3, - CO2 (CRC3RD3) tC (O) NRA3RB3, -OC (O) RA3, -CN, -C (O) NRA3RB3, -NRA3C (O) RB3, -NRA3CO2RB3, -OC (O) NRA3RB3, - NRA3C (O) NRA3RB3, -NRA3S (O) rRB3, -C RA3 (= N-ORB3), -C (= NRE3) RA3, -C (= NRE3) NRA3RB3, -NRA3C (= NRE3) NRA3RB3, - CHF2, -CF3, -OCHF2, and -OCF3, where alkyl, alkenyl , alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from RX; each R5 is independently selected from hydrogen, halogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, heterocyclyl, heterocyclyl-C1-4 alkyl, aryl , aryl-C1-4alkyl, heteroaryl, heteroaryl-C1-4alkyl, -NO2, -NRA4RB4, -ORA4, -SRA4, -S (O) rRA4, -S (O) 2ORA4, -OS (O) 2RB4, -S (O) rNRA4RB4, -P (O) RA4RB4, -P (O) (ORA4) (ORB4), - (CRC4RD4) tNRA4RB4, - (CRC4RD4) tORB4, - (CRC4RD4) tSRB4, - (CRC4RD4) tS O) rRB4, - (CRC4RD4) tP (O) RA4RB4, - (CRC4RD4) tP (O) (ORA4) (ORB4), - (CRC4RD4) tCO2RB4, - (CRC4RD4) tC (O) NRA4RB4, - (CRC4RD4) (O) RB4, - (CRC4RD4) tNRA4CO2RB4, - (CRC4RD4) tOC (O) NRA4RB4, - (CRC4RD4) tNRA4CONRA4RB4, - (CRC4RD4) tNRA4SO2NRA4RB4, -NRB4-CRC4-NRA4-CRC4, -NRB4-CRC4, -NRA4 CRC4RD4) tNRA4RB4, - S (O) r (CRC4RD4) tNRA4RB4, -C (O) RA4, -C (O) (CRC4RD4) tNRA4RB4, -C (O) (CRC4RD4) tORB4, -C (O) (CRC4RD4) tSRB4, - C (O) (CRC4RD4) tS (O) rRB4, -CO2RB4, -CO2 (CRC4RD4) tC (O) NRA4RB4, -OC (O) RA4, -CN, -C (O) NRA4RB4, -NRA4C ( O) RB4, - NRA4CO2RB4, -OC (O) NRA4RB4, -NRA4C (O) NRA4R B4, -NRA4S (O) rRB4, -CRA4 (= N-ORB4), -C (= NRE4) RA4, - C (= NRE4) NRA4RB4, -NRA4C (= NRE4) NRA4RB4, -CHF2, -CF3, -OCHF2 , and -OCF3, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from RX; each R6 is independently selected from hydrogen, halogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, heterocyclyl, heterocyclyl-C1-4 alkyl, aryl , aryl-C1-4 alkyl, heteroaryl, heteroaryl-C1-4 alkyl, -NO2, -NRA5RB5, -ORA5, -SRA5, -S (O) rRA5, -S (O) 2ORA5, -OS (O) 2RB5, -S (O) rNRA5RB5, -P (O) RA5RB5, -P (O) (ORA5) (ORB5), - (CRC5RD5) tNRA5RB5, - (CRC5RD5) tORB5, - (CRC5RD5) tSRB5, - (CRC5RD5) tS O) rRB5, - (CRC5RD5) tP (O) RA5RB5, - (CRC5RD5) tP (O) (ORA5) (ORB5), - (CRC5RD5) tCO2RB5, - (CRC5RD5) tC (O) NRA5RB5, - (CRC5RD5) (O) RB5, - (CRC5RD5) tNRA5CO2RB5, - (CRC5RD5) tOC (O) NRA5RB5, - (CRC5RD5) tNRA5CONRA5RB5, - (CRC5RD5) tNRA5SO2NRA5RB5, -NRA5) (CRC5RB5, -NRA5) (CRC5RB5) CRC5RD5) tNRA5RB5, - S (O) r (CRC5RD5) tNRA5RB5, -C (O) RA5, -C (O) (CRC5RD5) tNRA5RB5, -C (O) (CRC5RD5) tORB5, -C (O) (CRC5RD5) tSRB5, - C (O) (CRC5RD5) tS (O) rRB5, -CO2RB5, -CO2 (CRC5RD5) tC (O) NRA5RB5, -OC (O) RA5, -CN, -C (O) NRA5RB5, -NRA5C ( O) RB5, - NRA5CO2RB5, -OC (O) NRA5RB5, -NRA5C (O) NRA5R B5, -NRA5S (O) rRB5, -CRA5 (= N-ORB5), -C (= NRE5) RA5, - C (= NRE5) NRA5RB5, -NRA5C (= NRE5) NRA5RB5, -CHF2, -CF3, -OCHF2 , and -OCF3, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from RX; each RA1, RA2, RA3, RA4, RA5, RB1, RB2, RB3, RB4, and RB5 are independently selected from hydrogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3- cycloalkyl 10 -C 1-4 alkyl, heterocyclyl, heterocyclylC 1-4 alkyl, aryl, arylC 1-4 alkyl, heteroaryl, and heteroarylC 1-4 alkyl, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl they are unsubstituted or are substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from RX; or each "RA1 and RB1", "RA2 and RB2", "RA3 and RB3", "RA4 and RB4", and "RA5 and RB5", together with the atom or atoms to which they are attached, form a heterocyclic ring of 4 to 12 members containing 0, 1 or 2 additional heteroatoms independently selected from oxygen, sulfur and nitrogen, and optionally substituted with 1, 2, or 3 RX groups; Each RC1, RC2, RC3, RC4, RC5, RD1, RD2, RD3, RD4, and RD5 are independently selected from hydrogen, halogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, cycloalkyl C3-10-C1-4 alkyl, heterocyclyl, heterocyclylalkylC 1-4, aryl, aryl-C1-4 alkyl, heteroaryl, and heteroaryl-C1-4 alkyl, wherein alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, cycloalkoxy, alkylthio , cycloalkylthio, alkylamino, cycloalkylamino, heterocyclyl, aryl, and heteroaryl are unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from RX; or "RC1 and RD1", "RC2 and RD2", "RC3 and RD3", "RC4 and RD4", and "RC5 and RD5" together with the carbon atom or atoms to which they are attached form a ring of 3 to 12-membered containing 0, 1 or 2 heteroatoms independently selected from oxygen, sulfur, and nitrogen, and optionally substituted with 12 or 3 RX groups; each RE1, RE2, RE3, RE4, and RE5 are independently selected from hydrogen, C1-10 alkyl, CN, NO2, ORa2, SRa2, -S (O) rRa2, -C (O) Ra2, -S (O) rNRa2Rb2 , and -C (O) NRa2 kb2; each RX is independently selected from C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, heterocyclyl, heterocyclyl-C1-4 alkyl, aryl, aryl-alkyl C 1-4, heteroaryl, heteroaryl-C 1-4 alkyl, halogen, -NO2, -NRa1Rb1, -ORa1, -SRa1, -S (O) rRa1, -S (O) 2ORa1, -OS (O) 2Rb1, -S (O) rNRa1Rb1, -P (O) Ra1Rb1, - P (O) (ORa1) (ORb1), - (CRc1Rd1) tNRa1Rb1, - (CRc1Rd1) tORb1, - (CRc1Rd1) tSRb1, - (CRc1 (O) tS rRb1, - (CRc1Rd1) tP (O) Ra1Rb1, - (CRc1Rd1) tP (O) (ORa1) (ORb1), - (CRc1Rd1) tCO2Rb1, - (CRc1Rd1) tC (O) NRa1Rb1, - (CRc1Rd1) ) Rb1, - (CRc1Rd1) tNRa1CO2Rb1, - (CRc1Rd1) tOC (O) NRa1Rb1, - (CRc1Rd1) tNRa1C (O) NRa1Rb1, - (CRc1Rd1) tNRa1SO2NRa - (CRc1Rd1) tNRa1C (O) NRa1Rb1, - (CRc1Rd1) tNRa1SO2NRa - 1Rb1 (CRc1Rb1), CRc1Rb1 (tNRaR1) S (CRc1Rd1) tNRa1Rb1, -S (O) r (CRc1Rd1) tNRa1Rb1, -C (O) Ra1, - C (O) (CRc1Rd1) tNRa1Rb1, -C (O) (CRc1Rd1) tORb1, -C (O) ( CRc1Rd1) tSRb1, -C (O) (CRc1Rd1) tS (O) rRb1, -CO2Rb1, - |
| priorityDate | 2015-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1611.