http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2764848-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a0c3e4b714908382e152c4ee0b8ed0b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-32 |
| filingDate | 2011-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6849d91c7c56bcb52b789ed188f69f41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88162e6a128ae8ca27012e630fd25ef3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d0f258d09c8085c674194e02b6c31a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ae4a3be5e6607410d07badff8cce5bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cabd17ed59e613fd3c4449097bdefeb7 |
| publicationDate | 2020-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2764848-T3 |
| titleOfInvention | N- (1- (substituted phenyl) ethyl) -9H-purine-6-amines as PI3K inhibitors |
| abstract | A compound of Formula I: ** (See formula) ** or a pharmaceutically acceptable salt thereof; wherein: Ar is ** (See formula) ** R1 is selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted by 1, 2, 3, or 4 groups independently selected from halo, OH, CN, NR1aR2b, C1-6 alkoxy, and C1 -6 haloalkoxy; each R1a and R2b is independently selected from H and C1-6 alkyl; or any R1a and R2b together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group, which is optionally substituted with 1, 2, 3 or 4 substituents independently selected from C1-6 alkyl; R2 is selected from halo, CN, C1-6 alkyl, C1-6 haloalkyl, -L- (C1-6 alkyl), -L- (C1-6 haloalkyl), and -L- (C1-4 alkylene) n- Cy2 and - (C1-4 alkylene) n-Cy2; wherein said C1-6 alkyl in said C1-6 alkyl and -L- (C1-6 alkyl) is optionally substituted with 1, 2, 3 or 4 independently selected R2a groups; L is 0, NRB, S, S (O), S (O) 2, C (O), C (O) NRB, S (O) NRB, S (O) 2NRB, NRBC (O), NRBS (O ) and NRBS (O) 2; RA and RB are each independently selected from H and C1-6 alkyl; Cy2 is selected from C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl; each of which is substituted with p independently selected R2a groups; where p is 0, 1, 2, 3, or 4; each R2a is independently selected from OH, NO2, CN, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, amino , C1-6 alkylamino, di (C1-6 alkyl) amino, thio, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, carbamyl, C1-6 alkylcarbamyl, di (C1-6 alkyl) carbamyl, carboxy, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, C1-6 alkylsulfonylamino, aminosulfonyl, C1-6 alkylaminosulfonyl, di (C1-6 alkyl) aminosulfonyl, aminosulfonylamino, C1-6 alkylaminosulfonylamino, di (C1-6 alkyl) aminosulfonylamino, aminocarbonylamino, C1-6 alkylaminocarbonylamino, and di (C1-6 alkyl) aminocarbonylamino; R3 is halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, - (C1-4 alkylene) r-Cy3, ORa, SRa, C (O) Rb, C (O) NRCRd, C (O) ORa, OC (O) Rb, OC (O) NRCRd, NRCRd, NRcC (O) Rb, NRcC (O) ORb, NRfC (O) Rb, NRfC (O) ORb, NRcC (O) NRCRd, C (= NRe) Rb, C (= NRe) NRCRd, NRcC (= NRe) NRCRd, NRcS (O) Rb, NRcS (O) 2Rb, NRfS (O) 2Rb, NRcS (O) 2NRCRd, S (O) Rb, S (O) NRCRd, S (O) 2Rb, or S (O) 2NRCRd; wherein said C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with 1, 2, 3, or 4 independently selected R3a groups; Cy3 is selected from C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl; each of which is optionally substituted with 1, 2, 3, or 4 independently selected R3a groups; provided one of the following is true: ... |
| priorityDate | 2010-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1202.