| abstract |
An anti Aß N3pGlu antibody comprising a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein LCDR1 is KSX1X2SLLYSRX3KTYLN (SEQ ID NO: 51), LCDR2 is AVSKLX4S (SEQ ID NO: 52 ), LCDR3 is VQGTHYPFT (SEQ ID NO: 5) and HCDR1 is GYX5FTX6YYIN (SEQ ID NO: 53), HCDR2 is WINPGSGNTKYNEKFKG (SEQ ID NO: 8) and HCDR3 is EGX7TVY (SEQ ID NO: 54), where is S or T; X2 is Q or R, X3 is G or S, X4 is D or G, X5 is D or T, X6 is R or D and X7 is I, T, E or V, for use in the prevention of disease of Alzheimer's |