abstract |
A multivalent immunogenic composition comprising polysaccharide-protein conjugates consisting of individually conjugated pneumococcal capsular polysaccharides of Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F with CR-M197, comprising 1 to 5 µg of each polysaccharide; 20 to 100 µg / ml CRM197 carrier protein; from 0.02 to 2 mg / ml of elemental aluminum in the form of aluminum phosphate; 0.5 to 1.25% sodium chloride; 0.002 to 0.2% polysorbate 80; 1 to 10 mM sodium succinate buffer at pH 4 to 7; and 7 to 15 mg / ml of 2-phenoxyethanol. |