| abstract |
A compound of Formula I: ** Formula ** wherein: R1 is pyridyl, pyrimidinyl, or pyrazinyl, attached through a heteroaryl ring carbon atom, optionally substituted with 1, 2, or 3 R5 or wherein R1 is thiophenyl, quinolinyl, isoquinolinyl, benzofuranyl, benzothiophenyl, or pyrazolyl, each optionally substituted with 1, 2, or 3 R5; A and D are CH and B is CR2; each R2 is independently C1-10 alkyl, halo C1-10alkyl, halo, cyano, or -SO2C1-6 alkyl; R3 and R3a are independently hydrogen or C1-10 alkyl; R4 and R4a are independently hydrogen, C1-10 alkyl, C3-10 haloalkyl, C1-10 cycloalkyl, C1-10alkC3-10cycloalkyl or C1-10alkNR7R7a, where R7 and R7a are independently H or C1-10 alkyl, or R4 and R4a together with the nitrogen through which they are attached, form a piperdinyl, piperazinyl, pyrrolidinyl or morpholinyl ring, in which the nitrogen atom of the piperazinyl ring is optionally substituted with R6; each R5 is independently halo, cyano, hydroxy, C1-10 alkyl, C1-10 haloalkyl, C1-10 alkoxy, C1-10 haloalkoxy, C3-10 cycloalkyl, C3-10 cycloalkoxy, amino, C1-10 alkylamino, C1-10 dialkylamino 10, C3-10 cycloalkylamino, pyrrolidinyl, C1-10 alkylsulfonyl, sulfamoyl, C1-10 alkylsulfamoyl or C1-10 dialkylsulfamoyl; and R6 is C1-10 alkyl or acetyl; or a pharmaceutically acceptable salt, enantiomer, or diastereoisomer thereof. wherein the term "heteroaryl" refers to a one, two, three, or multiple ring aromatic ring system having 3 to 50 carbon atoms and including at least one ring member heteroatom, each ring member being heteroatom independently sulfur, oxygen or nitrogen and which is attached to the rest of the molecule through a carbon atom. |