http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2763417-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2014-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_671a37bb9c7033d32ba7ee2e594cd752 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1f8a369915641529fb573156f80434c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_169534ec847c0a19a7e8402e16b0abbe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e698493b7081e0866d522a049b201ae9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9596d1be459159076c9bf6e6c84f1aec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d916a76c3ba6aadad99a1ac99867d35 |
| publicationDate | 2020-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2763417-T3 |
| titleOfInvention | Novel octahydro-pyrrolo [3,4-c] -pyrrole derivatives and analogs thereof as autotaxin inhibitors |
| abstract | Compounds of formula (I) ** Formula ** wherein R1 is substituted C3-10 cycloalkyl, substituted C3-10 cycloalkyl-C1-12 alkyl, substituted phenyl, substituted phenyl-C1-12 alkyl, phenoxy-C1-12 alkyl substituted, substituted phenyl-C3-10 cycloalkyl, substituted phenyl-C2-7 alkenyl, substituted phenyl-C2-7 alkynyl, substituted naphthyl, substituted naphthyl-C1-12 alkyl, naphthyloxy-substituted C1-12 alkyl, naphthyl-C2 alkenyl -7 substituted, substituted pyridinyl, pyridinyl-substituted C1-12 alkyl, substituted pyridinyl-C2-7 alkenyl, substituted pyridinyl-C2-7 alkynyl, substituted thiophenyl, thiophenyl-substituted C1-12 alkyl, thiophenyl-substituted C2-7 alkenyl, C2-7 substituted thiophenyl-alkynyl, substituted indolyl, substituted quinolyl, substituted isoquinolyl, 2,3-dihydro-1H-isoindol-2-yl substituted, 1H-indol-2-yl substituted or benzofuran-2-yl substituted where substituted cycloalkyl, substituted cycloalkyl-C1-12alkyl, substituted phenyl, phenyl-substituted C1-12alkyl, pheno Substituted xi-C1-12 alkyl, substituted phenyl-C3-10 cycloalkyl, substituted phenyl-C2-7 alkenyl, substituted phenyl-C2-7 alkynyl, substituted naphthyl, substituted naphthyl-C1-12 alkyl, substituted naphthyloxy-C1-12 alkyl , substituted C2-7 naphthyl-alkenyl, substituted pyridinyl, substituted pyridinyl-C1-12 alkyl, substituted pyridinyl-C2-7 alkenyl, substituted pyridinyl-C2-7 alkynyl, substituted thiophenyl, thiophenyl-substituted C1-12 alkyl, thiophenyl-alkenyl C2-7 substituted, C2-7 substituted thiophenyl-alkynyl, substituted indolyl, substituted quinolyl, substituted isoquinolyl, 2,3-dihydro-1H-isoindol-2-yl substituted, 1H-indol-2-yl substituted and benzofuran-2- Substituted yl are substituted with R7, R8 and R9; R2 is substituted phenyl, substituted pyridinyl, substituted pyrrolyl, oxyhydropyridinyl, or substituted thiophenyl, wherein substituted phenyl, substituted pyridinyl, substituted pyrrolyl, and substituted thiophenyl are substituted with R10, R11, and R12; Y is -OC (O) -, -NR5C (O) -, -C (O) -, -S (O) 2-, ** Formula ** A is -N- or CH-; W is -O-, -S-, -NR6-, -C (O) -, -S (O) 2- or -CR3R4-; R3 and R4 are independently selected from H, halogen, C1-12 alkyl and C3-10 cycloalkyl; R5 and R6 are independently selected from H, C1-12 alkyl and C3-10 cycloalkyl; R7, R8, and R9 are independently selected from H, C1-12 alkyl, hydroxy-C1-12 alkyl, halo-C1-12 alkyl, hydroxyhalo-C1-12 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1- alkyl 12, C3-10 cycloalkyl-C1-12 alkoxy, C3-10 cycloalkoxy, C3-10 cycloalkoxy-C1-12 alkyl, C3-10 cycloalkyl-C1-12 alkoxy-C1-12 alkyl, C1-12 alkoxy, C1- alkoxy 12-C1-12 alkyl, halo-C1-12 alkoxy, C1-12 alkoxyhalo-C1-12 alkyl, C1-12 alkoxy-C1-12 alkoxy, C1-12 alkoxy-C1-12 alkoxy-C1-12 alkyl, phenyl , substituted phenyl, pyridinyl, substituted pyridinyl, halogen, hydroxy, cyano, C1-12 alkylsulfanyl, halo-C1-12 alkylsulfanyl, C3-10 cycloalkylsulfanyl, C1-12 alkylsulfinyl, halo-C1-12 alkylsulfinyl, C3-10 cycloalkylsulfinyl, alkylsulfonyl C1-12 halo-C1-12 alkylsulfonyl, C3-10 cycloalkylsulfonyl, substituted aminosulfonyl, substituted amino, and substituted amino-C1-12 alkyl, wherein the substituted aminosulfonyl, substituted amino, and substituted amino-C1-12 alkyl are substituted at the A nitrogen atom with one to two substituents independently selected from H, C1-12 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-12 alkyl, hydroxy-C1-12 alkyl, C1-12 alkoxy-C1-12 alkyl , C1-12 alkylcarbonyl and C3-10 cycloalkylcarbonyl, and wherein the substituted phenyl and substituted pyridinyl are optionally substituted with one to three substituents independently selected from C1-12 alkyl, halogen, halo-C1-12 alkyl, C1 alkoxy -12 and halo-C1-12 alkoxy, wherein at least one of R7, R8 and R9 is not H; R10 is substituted aminosulfonyl, C1-12 alkoxycarbonyl, C1-12 alkylcarbonylamino, C1-12 alkylsulfonylamino, substituted amino, carboxy, cyano, hydroxy, or tetrazolyl, wherein the substituted amino is substituted on the nitrogen atom with one to two substituents independently selected from H, C1-12 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-12 alkyl, hydroxy-C1-12 alkyl and C1-12 alkoxy-C1-12 alkyl; R11 and R12 are independently selected from H, C1-12 alkyl, C3-10 cycloalkyl, C1-12 alkoxy, halogen, and halo C1-12 alkyl; m, n, p, and q are independently selected from 1 or 2; or pharmaceutically acceptable salts. |
| priorityDate | 2013-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 272.