| abstract |
A solid, rapidly dispersible dosage form that disperses in 15 s or less when placed in 15 ml of an aqueous fluid, said dosage form comprising a non-compressed, porous, three-dimensionally printed bonded matrix comprising: (i) preparing particles containing the drug having an average, medium or median effective particle size of 50 to 400 μm and comprising (a) native oxcarbazepine (OXC) particles that do not contain any added excipients, (b) at least one disintegrant, (c) al less one surfactant, and (d) at least one binder; (ii) at least one disintegrant; and (iii) at least one binder; wherein in the drug containing particles, OXC is presented as a mixture of two different native drug powders, each having its own native drug particle size distribution and wherein the first effective particle size to size ratio OXC native particle size is> 1: 1 to 5: 1 relative to the first native OXC, and the second ratio of effective particle size to native OXC particle size is 20: 1 to 50: 1 relative to the second native OXC. |