http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2759775-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b7e473613f549ad747f3af840e73fac8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D291-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D515-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D515-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D515-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-554 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D515-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D515-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D291-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-20 |
| filingDate | 2016-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73f24308c9b13d4b2595e5c1fc0c36a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_281f8ec1d7693f35e197fa476b17fe0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16488b976437dea4696913f173e930b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e52478015ff82026f156fc82bff027e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a70d156f0cb85edd88cf0fa5e5c87937 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4db7eff0354ee37e648ecf0cb0efca3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca0ab94f0006281c4279076be44cef6d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3a61b0c6113608ce1e5bd03a2870f38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70101f2fbe4980b2bdc2dd8759931102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93570742cd576f5e06627eef9e5c05d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b374fc04490e32aa058b1e53eb96f9c2 |
| publicationDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2759775-T3 |
| titleOfInvention | Cyclic sulfamoylarylamide derivatives and their use as medicines for the treatment of hepatitis B |
| abstract | A compound of Formula (IA) ** Formula ** or a stereoisomer or a tautomeric form thereof, where ** Formula ** represents a 5- or 6-membered monocyclic aryl optionally containing one or two heteroatoms, such as aryl which is optionally substituted with one or more substituents, each independently selected from the group consisting of C1-C3 alkyl, C3-C4 cycloalkyl, -CN and halogen; represents a phenyl or pyridyl; X represents -CR2R3-; Y represents C1-C7 alkanediyl or C2-C7 alkenodiyl, each optionally substituted with one or more substituents each independently selected from the group consisting of C1-C4 alkyl, fluoro and -OH; Z represents a heteroatom or a single bond; Ra, Rb, Rc and Rd are each independently selected from the group consisting of hydrogen, halogen, -CHF2, -CF2-methyl, -CH2F, -CF3, -OCF3, -CN, C3-C4 cycloalkyl and - (alkyl C1-C4); R1 is hydrogen or C1-C10 alkyl optionally substituted with one or more substituents, each independently selected from the group consisting of -OH, fluoro and oxo; R2 is selected from the group consisting of hydrogen; C1-C10 alkyl optionally substituted with one or more substituents, each independently selected from the group consisting of -OH, fluoro, methoxy, oxo and -C (= O) O (C1-C4 alkyl); (C1-C3 alkyl) -R7; C2-C4 alkynyl; a 3-7 membered saturated ring optionally containing one or more heteroatoms, each independently selected from the group consisting of O, S, and N; and a monocyclic aryl optionally containing one or two heteroatoms; where the (C1-C3 alkyl) -R7, 3-7 membered saturated ring or monocyclic aryl are each optionally substituted with one or more R8 substituents, R3 is hydrogen or C1-6 alkyl optionally substituted with -OH; or R2 and R3, together with the carbon atom to which they are attached, form a 3-7 membered saturated ring optionally containing one or more heteroatoms, each independently selected from the group consisting of O, S and N, and which is optionally substituted with one or more substituents, each independently selected from the group consisting of -OH, fluoro, methoxy, oxo, -C (= O) O (C1-C4 alkyl), benzyl and C1-C4 alkyl optionally substituted with one or more substituents, each independently selected from fluoro and / or -OH; R7 represents a monocyclic aryl optionally containing one or two heteroatoms and optionally substituted with one or two substituents, each independently selected from the group consisting of halo and C1-3alkyl; a 3-7 membered saturated ring optionally containing one or more heteroatoms, each independently selected from the group consisting of O, S, and N; or -NR9R10; where R9 and R10 are each independently selected from hydrogen and C1-C3 alkyl optionally substituted with one or more fluoro substituents; Each R8 is independently selected from the group consisting of -OH, fluoro, methoxy, oxo, -C (= O) O (C1-C4 alkyl), (C1-C4 alkyloxy) (C1-C4 alkyloxy), and C1- alkyl C4 optionally substituted with one or more substituents, each independently selected from fluoro and / or -OH; or a pharmaceutically acceptable salt or a solvate thereof. |
| priorityDate | 2015-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 164.