http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2759507-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 |
| filingDate | 2014-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42a6c9103e0a2bd8ca7af96e375a29ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84935b63dfde400b8e8a79dd4663914e |
| publicationDate | 2020-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2759507-T3 |
| titleOfInvention | Method to predict a treatment response to a V1B antagonist in a patient with depressive and / or anxiety symptoms |
| abstract | Method for predicting a treatment response to a vasopressin 1B receptor antagonist (V1B receptor) in a patient with depressive and / or anxiety symptoms, comprising the following steps: (i) determining the presence or absence of at least one polymorphic variant in the vasopressin receptor 1B gene (AVPR1B) in a nucleic acid sample from said patient, where a polymorphic variant in the AVPR1B gene is the SNP rs28373064 that is represented by a single polymorphic change in position 27 of SEQ ID NO: 1, where in one or two alleles the wild type nucleotide A is replaced by the indicator nucleotide G, and (ii) determine the presence or absence of at least one polymorphic variant in the patient's genome, excluding the AVPR1B gene , in the nucleic acid sample of said patient, where the at least one polymorphic variant in the patient's genome, excluding the AVPR1B gene, is selected from the group of biomarkers consisting of: - SNP rs9880583 which is represented by a single polymorphic change at position 27 of SEQ ID NO: 2, where in one or two alleles the wild type nucleotide C is replaced by the reporter nucleotide G, - SNP rs13099050 which is represented by a single polymorphic change at position 27 of SEQ ID NO: 3, where in one or two alleles the wild type nucleotide A is replaced by reporter nucleotide C, - SNP rs7441352 which is represented by a single polymorphic change in the position 27 of SEQ ID NO: 4, where in one or two alleles the wild type nucleotide A is replaced by reporter nucleotide G, - SNP rs730258 which is represented by a single polymorphic change in position 27 of SEQ ID NO: 5, wherein in one or two alleles the wild-type C nucleotide is replaced by the reporter nucleotide T, - SNP rs12654236 which is represented by a single polymorphic change at position 27 of 35 SEQ ID NO: 6, in where in a oo two alleles the wild type nucleotide A is replaced by the reporter nucleotide G, - SNP rs 17091872 which is represented by a single polymorphic change at position 27 of SEQ ID NO: 7, where in one or two alleles the nucleotide Wild type A is replaced by reporter nucleotide G, - SNP rs12254219 which is represented by a single polymorphic change at position 27 of SEQ ID NO: 8, where in one or two alleles the wild type nucleotide C is replaced by reporter nucleotide T, - SNP rs11575663 which is represented by a single polymorphic change at position 27 of SEQ ID NO: 9, where in one or two alleles the wild type nucleotide A is replaced by reporter nucleotide G , - SNP rs7416 which is represented by a single polymorphic change at position 27 of 55 SEQ ID NO: 11, where in one or two alleles the wild type nucleotide A is replaced by the indicator nucleotide G, - SNP rs12424513 qu e is represented by a single polymorphic change at position 27 of SEQ ID NO: 12, where in one or two alleles the wild type nucleotide C is replaced 60 by the reporter nucleotide T, - SNP rs1035050 which is represented by a single polymorphic change at position 27 of SEQ ID NO: 13, where in one or two alleles the wild type nucleotide C is replaced by the reporter nucleotide T, - SNP rs9959162 which is represented by a single polymorphic change in position 27 of SEQ ID NO: 14, wherein in one or two alleles the wild type nucleotide A is replaced by reporter nucleotide C, and - SNP rs8088242 which is represented by a single polymorphic change at position 27 of SEQ ID NO: 15, where in one or two alleles the wild-type nucleotide A is replaced by reporter nucleotide G, where the combination of the presence or absence of at least one polymorphic variant in the AVPR1B 10 gene with the presence or absence of ia of at least one polymorphic variant in the patient's genome, excluding the AVPR1B gene, is indicative of the treatment response. |
| priorityDate | 2013-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 147.