abstract |
An isolated therapeutic human antibody or antigen-binding portion thereof, comprising a heavy chain variable region (VH) according to SEQ ID NO: 12 and a light chain variable region (VL) according to SEQ ID NO: 43, and wherein said antibody or antigen-binding portion thereof specifically binds to homodimeric IL-17A and heterodimeric IL-17AF, but does not specifically bind to homodimeric IL-17F. |