http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2758377-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37629fa7c35016ee77d00364d195f483 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6848 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2016-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b4fd399f13ef8ce9f0adba1ef8df742 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1d2d8684a46fd60cc872ae78b808489 |
| publicationDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2758377-T3 |
| titleOfInvention | A method to quantify anti-TNF antibodies |
| abstract | A method of quantifying a therapeutic anti-TNF antibody in a sample from a human individual comprising the steps of: a) adding to a test sample that may contain therapeutic anti-TNF antibodies a known amount of two or more labeled forms of said anti-TNF antibodies selected from a group comprising infliximab, etanercept, adalimumab, certolizumab, and golimumab, whereby a preproteolysis sample is provided, b) subjecting the preproteolysis sample to enzymatic proteolysis, to provide a proteolysis sample comprising (i) proteolysis-labeled peptides derived from the labeled anti-TNF antibodies and (ii) proteolysis peptides derived from the anti-TNF antibody contained in the test sample, c) determining by mass spectrometry analysis the ratio between (i) one or more selected proteolysis-labeled peptides and (ii) one or more corresponding proteolysis peptides derived from said antibody anti-TNF, d) calculating from the ratio determined in step c) the amount of said anti-TNF antibody in the test sample. |
| priorityDate | 2015-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 139.