http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2754480-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b09584fcdc1896646c7d1863a083d1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e13cf25eb1bef6199475314477618b46 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4353 |
| filingDate | 2016-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7020a9eee81f889f97e7a28b5e5bda37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c0841a0c00d0a4d06f403682080eeea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_244128838920c5c1f41c62b6d35ebf34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_689ec7105f588c23a0b3668e7640a4f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_626ad036e216a827b5e58e370e921801 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cd7c9d8cae29b885f70734b293b8c79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c907fd45eac5b612589b582dbe99edd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83402e500c742df0b30d0fafe0b65a20 |
| publicationDate | 2020-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2754480-T3 |
| titleOfInvention | Pyrido-oxazinone derivatives as TNAP inhibitors |
| abstract | A compound represented by the following general formula (I): ** Formula ** in which R1 represents a hydrogen atom, a C1-6 alkyl group (in which the alkyl group is optionally substituted with one to three groups, the which can be the same or different, selected from the following substituents: a hydroxy group, a C1-6 alkoxy group optionally substituted with one to three groups, which can be the same or different halogen groups, an amino group optionally substituted with one or two groups, which may be the same or different C1-6 alkyl groups, a C6-10 aryl group optionally substituted with one or two groups selected from the substituent group AB, a 3- to 10-membered heterocyclyl group containing one to four heteroatoms , which may be the same or different, selected from nitrogen, oxygen and sulfur and optionally substituted with one or two groups selected from the substituent group AB, a carboxyl group, a C1-6 alkylcarbonyl group, a C1-6 alkoxycarbonyl group, an aminocarbonyl group optionally substituted with one or two groups, which may be the same or different C1-6 alkyl groups, a saturated 4- to 7-membered heterocyclylcarbonyl group containing one or two heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur, an aminocarbonyloxy group optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups, a saturated 4 to 4 heterocyclylcarbonyloxy group 7-membered containing one or two heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur), a C3-8 cycloalkyl group (in which the cycloalkyl group is optionally substituted with one to three groups, which they can be the same or different, selected from the following substituents: a hydroxy group, a C1-6 alkoxy group optionally substituted with one to three groups os, which can be the same or different halogen groups, a C3-8 cycloalkyl group optionally substituted with one to three groups, which can be the same or different halogen groups, a C6-10 aryl group optionally substituted with one or two groups, which can be the same or different halogen groups, a 3 to 10 membered heterocyclyl group containing one to four heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur and optionally substituted with one or two groups, which can be the same or different halogen groups, a carboxyl group, a C1-6 alkylcarbonyl group, a C1-6 alkoxycarbonyl group, an aminocarbonyl group optionally substituted with one or two groups, which can be the same or C1-6 alkyl groups different, a saturated 4- to 7-membered heterocyclylcarbonyl group containing one or two heteroatoms, which may be the same or different, selected from nitrogen no, oxygen and sulfur, an aminocarbonyloxy group optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups, a saturated 4- to 7-membered heterocyclylcarbonyloxy group containing one or two heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur, a halogen group and a cyano group), a C6-10 aryl group (in which the aryl group is optionally substituted with one or two groups, which may be the same or different , selected from the following substituents: a hydroxy group, a C1-6 alkyl group optionally substituted with one to three groups, which can be the same or different halogen groups, a C3-8 cycloalkyl group optionally substituted with one to three groups, the which can be the same or different halogen groups, a C1-6 alkoxy group optionally substituted with one to three groups, which can be the same or different halogen groups, a group po C6-10 aryl optionally substituted with a group selected from the substituent group AB, a 3- to 10-membered heterocyclyl group containing one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur and optionally substituted with a group selected from the substituent group AB, a carboxyl group, an amino group optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups, a C1-6 alkoxycarbonyl group, an aminocarbonyl group optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups, a saturated 4- to 7-membered heterocyclylcarbonyl group containing one or two heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur, an aminocarbonyloxy group optionally substituted with one or two groups, which may be the same or different C1-6 alkyl groups, a saturated 4- to 7-membered heterocyclylcarbonyloxy group containing one or two heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur, a halogen group and a cyano group), or a 3- to 10-membered heterocyclyl group that contains one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur (in which the heterocyclyl group is optionally substituted with one or two groups, which may be the same or different, groups selected from the following substituents: a hydroxy group, a C1-6 alkyl group optionally substituted with one to three groups, which can be the same or different halogen groups, a C3-8 cycloalkyl group optionally substituted with one to three groups, which can be groups same or different halogens, a C1-6 alkoxy group optionally substituted with one to three groups, which may be the same or different halogen groups tes, a C6-10 aryl group, a 3- to 10-membered heterocyclyl group containing one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur, a carboxyl group, an amino group, a aminocarbonyl group optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups, a saturated 4- to 7-membered heterocyclylcarbonyl group containing one or two heteroatoms, which can be the same or different, selected from nitrogen , oxygen and sulfur, an aminocarbonyloxy group optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups, a saturated 4- to 7-membered heterocyclylcarbonyloxy group containing one or two heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur, a halogen group and a cyano group), R2 and R3 are the same or different and each represent a hydrogen atom oxygen, a C1-6 alkyl group (in which the alkyl group is optionally substituted with one to three groups, which may be the same or different, selected from the following substituents: a hydroxy group, an optionally substituted C1-6 alkoxy group with a group selected from the substituent group AC, a C3-8 cycloalkyl group optionally substituted with a group selected from the substituent group AB, a C6-10 aryl group optionally substituted with one or two groups selected from the substituent group AB, a group 3- to 10-membered heterocyclyl containing one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur and optionally substituted with one or two groups selected from the substituent group AB, a carboxyl group, a group C1-6 alkylcarbonyl, a C1-6 alkoxycarbonyl group, an amino group optionally substituted with one or two groups, which may be alkyl groups The same or different C1-6 alkyl groups, an aminocarbonyl group optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups, a saturated 4- to 7-membered heterocyclylcarbonyl group containing one or two heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur, an aminocarbonyloxy group optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups, a saturated 4- to 7-membered heterocyclylcarbonyloxy group containing one or two heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur, a halogen group and a cyano group), a C6-10 aryl group (in which the aryl group is optionally substituted with one or two groups, which may be the same or different, selected from the following substituents: a hydroxy group, a C1-6 alkoxy group optionally substituted with one to three groups, the c These can be the same or different halogen groups, a C1-6 alkyl group optionally substituted with a group selected from the substituent group AD, a C3-8 cycloalkyl group optionally substituted with a group selected from the substituent group AD, a C6 aryl group 10 optionally substituted with a group selected from the substituent group AD, a 3- to 10-membered heterocyclyl group containing one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur and optionally substituted with a group selected from the substituent group AD, an amino group optionally substituted with one or two groups, which may be the same or different C1-6 alkyl groups, a carboxyl group, a C1-6 alkylcarbonyl group, a C1-6 alkoxycarbonyl group, a aminocarbonyl group optionally substituted with one or two groups, which may be the same or different C1-6 alkyl groups, a heterocyclic group 4 to 7-membered saturated carbonyl containing one or two heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur, an aminocarbonyloxy group optionally substituted with one or two groups, which can be C1-6 alkyl groups the same or different, a saturated 4- to 7-membered heterocyclylcarbonyloxy group containing one or two heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur, a halogen group and a cyano group), a heterocyclyl group of 3 to 10 members containing one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur (in which the heterocyclyl group is optionally substituted with one or two groups, which may be the same or different , selected from the following substituents: a hydroxy group, a C1-6 alkoxy group optionally substituted with one to three groups, which can be r same or different halogen groups, a C1-6 alkyl group optionally substituted with a group selected from the substituent group AD, a C3-8 cycloalkyl group optionally substituted with a group selected from the substituent group AD, a C6-10 aryl group optionally substituted with a group selected from the substituent group AD, a 3 to 10 membered heterocyclyl group containing one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur and optionally substituted with a group selected from the substituent group AD, an amino group optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups, a carboxyl group, a C1-6 alkylcarbonyl group, a C1-6 alkoxycarbonyl group, an aminocarbonyl group optionally substituted with one or two groups, which may be the same or different C1-6 alkyl groups, a satu heterocyclylcarbonyl group 4- to 7-membered ring containing one or two heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur, an aminocarbonyloxy group optionally substituted with one or two groups, which can be the same C1-6 alkyl groups or different, a saturated 4- to 7-membered heterocyclylcarbonyloxy group containing one or two heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur, a halogen group and a cyano group), a C1-6 alkylcarbonyl group (in which the alkylcarbonyl group is optionally substituted with one to three groups, which may be the same or different, selected from the substituent group AE), a C6-10 arylcarbonyl group (in which the arylcarbonyl group is optionally substituted with one or two groups, which may be the same or different, selected from the substituent group AE and a halogeno C1-6 alkyl group), a heterocyclylcarbonyl group of 3 to 10 members containing from one to four heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur (in which the heterocyclylcarbonyl group is optionally substituted with one or two groups, which can be the same or different, selected from the substituent group AE and a C1-6 haloalkyl group), a carboxyl group, a C1-6 alkoxycarbonyl group (in which the alkoxycarbonyl group is optionally substituted with one to three groups, which may be the same or different, selected between the substituent group AF), an aminocarbonyl group (in which the aminocarbonyl group is optionally substituted with one or two groups, which may be the same or different C1-6 alkyl groups each optionally substituted with one to three groups, which may be the same or different, selected from the substituent group AF), a C6-10 arylaminocarbonyl group (in which the arylaminocarbonyl group is opt ionally substituted with one or two groups, which may be the same or different, selected from the substituent group AE and a C1-6 halogenoalkyl group), a saturated 4- to 7-membered heterocyclylcarbonyl group containing one or two heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur (in which the heterocyclylcarbonyl group is optionally substituted with one to three groups, which may be the same or different, selected from the substituent group AF), or a heterocyclylaminocarbonyl group of 3 to 10 members containing one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur (in which the heterocyclylaminocarbonyl group is optionally substituted with one or two groups, which may be the same or different, selected from the substituent group AE and a C1-6 haloalkyl group), or the C1-6 alkyl groups of R2 and R3 are attached or optionally to each other to form a 3- to 6-membered saturated carbocyclic ring or to form a 4- to 6-membered saturated heterocyclic ring through a nitrogen or oxygen atom (wherein a nitrogen atom in the saturated heterocyclic ring 4-6 membered is optionally replaced with a hydrogen atom, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C1-6 alkoxycarbonyl group), R4 and R5 are the same or different and each represents a carbon atom. hydrogen, a C1-6 alkyl group (in which the alkyl group is optionally substituted with one to three groups, which may be the same or different, selected from the substituent group AG), a C6-5 aryl group (in the that the aryl group is optionally substituted with one or two groups, which may be the same or different, selected from the substituent group AG), or a 3- to 10-membered heterocyclyl group containing one to four heteroatoms, which may n be the same or different, selected from nitrogen, oxygen and sulfur (in which the heterocyclyl group is optionally substituted with one or two groups, which may be the same or different, selected from the substituent group AG), R6 represents an atom of hydrogen, a hydroxyl group or a C1-6 alkyl group (R6 is a carbon substituent on the pyridinyl ring, not a nitrogen substituent), each R7 substituent may be the same or different and each represents a C1-6 alkyl group ( wherein the alkyl group is optionally substituted with one to three groups, which may be the same or different, selected from the substituent group AH), a C1-6 alkoxy group (wherein the alkoxy group is optionally substituted with one to three groups, which may be the same or different, selected from the substituent group AH), a halogen group, a C6-10 aryl group (in which the aryl group is optionally substituted with one or two groups os, which may be the same or different, selected from the substituent group AG), a 3 to 10-membered heterocyclyl group containing one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur ( in which the heterocyclyl group is optionally substituted with one or two groups, which may be the same or different, selected from the substituent group AG), a hydroxy group, an amino group (in which the amino group is optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups each optionally substituted with one to three groups, which can be the same or different, selected from the substituent group AJ), a carboxyl group, a C1 alkoxycarbonyl group -6 (in which the alkoxycarbonyl group is optionally substituted with one to three groups, which may be the same or different, selected from the substituent group AJ), an aminocarbonyl group (wherein the aminocarbonyl group is optionally substituted with one or two groups, which may be the same or different C 1-6 alkyl groups, each optionally substituted with one to three groups, which may be the same or different, selected between the substituent group AJ), or a cyano group, X represents -CH =, -C (-R7) = or -N =, m represents an integer selected from 1 to 4, and the substituent groups represent AB: a group hydroxy, a C1-6 alkyl group (in which the alkyl group is optionally substituted with one to three halogen groups), a C1-6 alkoxy group (in which the alkoxy group is optionally substituted with one to three halogen groups) , a halogen group, an amino group and a cyano group; AC: a C6-10 aryl group, a 3- to 10-membered heterocyclyl group containing one to four heteroatoms, which can be the same or different, selected from nitrogen, oxygen and sulfur and a halogen group; AD: a hydroxy group, a C1-6 alkoxy group, an amino group, a halogen group and a cyano group; AE: a hydroxy group, a C1-6 alkoxy group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 3- to 10-membered heterocyclyl group containing one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur, an amino group (in which the amino group is optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups), a halogen group and a cyano group ; AF: a C1-6 alkoxy group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 3- to 10-membered heterocyclyl group containing one to four heteroatoms, which can be the same or different, selected from nitrogen , oxygen and sulfur, a halogen group and a cyano group; AG: a hydroxy group, a C1-6 alkoxy group, an amino group (in which the amino group is optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups), a halogen group and a cyano group; AH: a hydroxy group, a C1-6 alkoxy group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 3- to 10-membered heterocyclyl group containing one to four heteroatoms, which may be the same or different , selected from nitrogen, oxygen and sulfur, a carboxyl group, a C1-6 alkoxycarbonyl group, an aminocarbonyl group (in which the aminocarbonyl group is optionally substituted with one or two groups, which may be the same or the same C1-6 alkyl groups or different), an amino group (in which the amino group is optionally substituted with one or two groups, which can be the same or different C 1-6 alkyl groups), a halogen group and a cyano group; and AJ: a C1-6 alkoxy group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 3- to 10-membered heterocyclyl group containing one to four heteroatoms, which may be the same or different, selected from nitrogen, oxygen and sulfur, a carboxyl group, a C1-6 alkoxycarbonyl group, an aminocarbonyl group (in which the aminocarbonyl group is optionally substituted with one or two groups, which can be the same or different C1-6 alkyl groups), a halogen group and a cyano group or a pharmacologically acceptable salt thereof. |
| priorityDate | 2015-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 434.