| abstract |
Procedure for obtaining optically active pirlindole enantiomers, in the form of a free base or in the form of a pharmaceutically acceptable salt characterized by carrying out a resolution by crystallization with optically active acids of (rac) -pirlindol in the form of a free base, in the that such procedure comprises the isolation of (rac) -pirlindol in the form of a free base, dissolving it in an organic solvent selected from the group consisting of: methanol, ethanol, propanol, 1-butanol, 2-butanol, tert-butyl alcohol, 2 -butanone, acetone, ethyl methyl ketone, methyl isobutyl ketone, dimethyl sulfoxide, 1,2-dichloroethane, diethyl ether, dimethyl ether, dimethylformamide, methyl tert-butyl ether, 2-propanol, pyridine, toluene, xylene or mixtures thereof in any proportion, adding the optically active acid and stirring the suspension from 15 minutes to 2 hours as well as using an organic solvent selected from the same group in the purification. |