| abstract |
RNA-containing composition for use in the treatment or prophylaxis of tumor and / or cancer diseases, wherein the RNA-containing composition comprises at least one coding RNA, comprising at least one coding region encoding at least one cytokine, or a fragment or variant thereof, where the cytokine is interleukin -12 (IL-12), where the fragment or variant has the same biological function or specific activity compared to the full-length native protein, where the at least one RNA encoding is an mRNA, where the RNA-containing composition is applied intratumorally and where the patient has received or is receiving a checkpoint modulator selected from a CTLA4 inhibitor and a PD-1 pathway inhibitor. |