http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2752675-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d4df3002ebd3af81260e2372d2d0e80 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-942 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56966 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5091 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate | 2018-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77614b0a1a5e30c6b4aabaa22ca19f68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_322ada19fff20588025e7e3427b59857 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e43b6df05d07a541d77499302358531 |
| publicationDate | 2020-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2752675-A1 |
| titleOfInvention | Platelet functionality for very early diagnosis of Parkinson's disease |
| abstract | Method for the diagnosis of Parkinson's disease based on detecting very low serotonin levels in the platelets of patients. Initial studies have not found normal serotonin levels in patients, whether or not they were treated with L-DOPA. Likewise, the platelets of patients have an altered ability to accumulate serotonin. This condition appears to be due to a deficient capacity of the platelet secreting vesicles of patients to accumulate biogenic amines. Given that the biological mechanisms underlying this problem are common in platelets and dopaminergic neurons, this could explain (given the toxicity of dopamine and its metabolites when they are free in the cytosol) the progressive death of these neurons in Parkinson's. As the involvement of the uptake mechanisms is due to problems in the proteins that mediate their accumulation, this functional failure probably precedes the appearance of the symptoms of the disease by several years. The very early detection of problems in the management of serotonin in platelets can detect possible patients with enough anticipation to establish specific neuroprotective measures. |
| priorityDate | 2018-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.