http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-275140-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d629f98a51b15993f56f9e04fdea237f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1962-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1962-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-275140-A1 |
| titleOfInvention | PROCEDURE TO PREPARE A 1,1-DIOXIDE OF 3-OXO OR 3-IMINO-3,4-DIHYDRO-1,2,4-BENZOTIADIAZINE |
| abstract | The invention comprises 3-oxo- and 3-imino-3,4-dihydro-1, 2, 4-benzothiadiazine1-, 1-dioxides having the structural formulae <FORM:0975925/C1/1> <FORM:0975925/C1/2> <FORM:0975925/C1/3> <FORM:0975925/C1/4> <FORM:0975925/C1/5> <FORM:0975925/C1/6> and their non-toxic alkali metal salts, wherein X represents trifluoromethyl or halogen, located at the 6- or 7-position, and Y represents hydrogen, alkyl having from 1-5 carbon atoms, trifluoromethyl or halogen at one of the unsubstituted positions 6, 7 or 8 and processes for the preparation thereof by reacting an appropriately X and Y substituted o-sulphamylaniline compound with at least molar equivalent quantities of urea or guanidine, and if desired reacting the product with the appropriate base to obtain the corresponding alkali metal salt thereof. o-Sulphamylaniline compounds of the formula <FORM:0975925/C1/7> are prepared by chlorosulphonating the appropriate aniline and treating the chlorosulphonyl aniline so obtained with ammonia. Alternatively proceeding by the scheme below an o-nitrochlorobenzene is treated with thiourea and benzyl chloride to yield a benzyl thio compound II, II is treated with chlorine and ammonia to form a nitrosulphonamide III and III is reduced to obtain the desired o-sulphamyl-aniline. <FORM:0975925/C1/8> <FORM:0975925/C1/9> <FORM:0975925/C1/10> <FORM:0975925/C1/11> Pharmaceutical compositions having anti-hypertensive action and containing compounds of the formulae above or non-toxic alkali metal salts thereof are employed enterally or parenterally in tablets and capsules or in liquid forms, e.g. elixirs, emulsions and injectables. |
| priorityDate | 1961-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.