http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2750276-T3

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publicationDate 2020-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2750276-T3
titleOfInvention Intrauterine system
abstract An intrauterine device for long-term insertion into a uterine cavity comprising a reservoir and a closed and continuous flexible structure in a polygonal shape, wherein at least one end of the reservoir is connected to the interior surface of the structure and the reservoir comprises the minus one therapeutically active substance, characterized in that the structure comprises a thermoplastic polyurethane elastomer comprising the reaction product of a) an isocyanate component that is 1,6-hexamethylene diisocyanate, b) a polyol component that is a polycarbonate diol prepared from 1,6-hexanediol and dimethyl carbonate, wherein said polycarbonate diol has a number average molecular weight of between 1000 and 2500 g / mol, c) a chain extender component comprising: c1) between 35 and 100 mol% of at least one difunctional chain extender having a number average molecular weight of between 118 and 286 g / mol and c2) between 0 and 65 mol% of a chain extender with a number average molecular weight between 104 and 500 g / mol, which is different from chain extender c1), which corresponds to formula (I) or formula (II) where R1 represents a branched alkylene radical or unbranched with between 1 and 12 carbon atoms or a substituted or unsubstituted alkylene radical with between 6 and 24 carbon atoms, R2, R4 each represents a branched or unbranched alkylene radical with between 1 and 12 carbon atoms or a radical alkoxyalkylene with between 1 and 12 C atoms or a substituted or unsubstituted alkylene radical with between 6 and 24 C atoms or a substituted or unsubstituted alkoxyarylene radical with between 6 and 24 C atoms, R3 represents a branched or unbranched alkylene radical with between 1 to 8 carbon atoms or a substituted or unsubstituted alkarylene radical with 6 to 20 carbon atoms or a substituted or unsubstituted arylene radical with 6 to 20 carbon atoms or a substituted or unsubstituted aralkylene radical with 6 to 20 carbon atoms C, n, m represent ntan each from 0 to 10, where n + m> = 1, and p represents from 1 to 10, d) optionally monofunctional alcohols as chain terminators, in the presence of e) one or more catalysts, with the addition of f) between 0.1 and 35% w / w, based on the weight of the thermoplastic polyurethane prepared with components a) to d), of inorganic fillers, g) optionally, additional additives and / or auxiliary substances in which the ratio of isocyanate groups from a) to the isocyanate-reactive groups of b), c) and d) is between 0.9: 1 and 1.1: 1.
priorityDate 2009-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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