| abstract |
A compound of 7- (morpholinyl) -2- (N-piperazinyl) methyltiene [2,3-c] pyridine of Formula-I or a pharmaceutically acceptable salt thereof, ** Formula ** in which: R1 is H, C1-C6 alkyl, C3-C6 cycloalkyl, -C (O) R5, -S (O) 2R5, -C (O) 2R5, C1-C6 alkyl substituted with R6, C3-C6 cycloalkyl substituted with R6, aryl, aryl substituted with R6 or heteroaryl substituted with R6; R2, R3 and R4 are each independently H, -OH, -SH, halo, amino, cyano, -nitro, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, -C (O) R5, -S (O) 2R5, -C (O) 2R5, -C = C (H) -R6, aminocarbonyl substituted with R6, alkylamino group substituted with R6 and optionally containing C3-C6 cycloalkyl, alkylaminocarbonyl, heteroaryl optionally substituted with H or amino, bicyclic heteroaryl or condensed tricyclic containing 1, 2 or 3 heteroatoms selected from N, O and S, or aryl optionally substituted with hydroxyl, hydroxylalkyl, amino, aminoalkyl, aminocarbonyl, cyano, halogen, aryloxy or R6; R5 is H, alkyl, amino, aryl substituted with R6, heteroaryl substituted with R6, condensed heteroaryl substituted with R6 or -trifluoromethyl; R6 is H, hydroxy, halogen, cyano, nitro, amino or C1-C6 alkyl. |