http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2749157-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b2a58b1af4d43f099830cb7a6a2cbd6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-08 |
| filingDate | 2014-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93082ce330d13e0fa7a4892df3dee314 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c318ef958341f9c55d5d632cb6118da1 |
| publicationDate | 2020-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2749157-T3 |
| titleOfInvention | Convenient preparation of N-substituted morphinan-6-oles from morphinan-6-one |
| abstract | A method of preparing a compound of formula (I) ** Formula ** comprising the method of contacting a compound of formula (II) ** Formula ** with a boron-based reducing agent, and a carbonyl compound having the formula: ** Formula ** where the contact is made in a solvent and an acid; and where in each case, --- is a simple link; L is absent; n is 1; R1 is H, C1-C6 alkyl, C1-C6 alkoxy, OH or -O-Pro; R2 is H, C1-C6 alkyl, C1-C6 alkoxy, OH or -O-Pro; R3 is H, C1-C6 alkyl, C1-C6 alkoxy, OH or -O-Pro, where Pro, in each case, is independently a hydroxyl protecting group; R10 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, -C1-C6-alkyl-aryl, -C2-C6-alkenyl-aryl, -C2-C6-alkynyl-aryl, - (C 1 -C 6 -alkyl) heteroaryl, -C2-C6-alkenyl heteroaryl, -C2-C6-alkynyl-heteroaryl, -C1-C6-alkyl-heterocycloalkyl, -C2-C6-alkenyl-heterocycloalkyl, -C2-C6-alkynyl ) heterocycloalkyl, -C1-C6-alkyl-C3-C8-cycloalkyl, -C2-C6-alkenyl-C3-C8-cycloalkyl, -C2-C6-alkynyl-C3-C8-cycloalkyl or C1-C6-alkoxy-C1-alkyl -C6; and R11 is H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, -C1-C6-alkyl-aryl, -C2-C6-alkenyl-aryl, -C2-C6-alkynyl aryl, -C1-C6-alkyl-heteroaryl, -C2-C6-alkenyl heteroaryl, -C2-C6-alkynyl heteroaryl, -C1-C6-alkylcycloalkyl, -C2-C6-alkenyl heterocycloalkyl, -alkynyl ( C2-C6) heterocycloalkyl, -C1-C6-alkyl-C3-C8-cycloalkyl, -C2-C6-alkenyl-C3-C8-cycloalkyl-C2-C6-alkynyl-C3-C8-cycloalkyl or C1-C6-alkoxy ) C1-C6 alkyl; wherein each aryl group is independently phenyl or naphthyl, and each aryl is unsubstituted or substituted at one or more positions substitutable with a group that is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1- alkoxy C6, OPro, halo, C1-C6 haloalkyl, or C1-C6 haloalkoxy; wherein each heteroaryl group is independently pyrrolyl, imidazolyl, triazolyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, triazinyl, indolyl, quinolinyl, furanyl, benzofuranyl, thienyl, or benzothienyl, and each heteroaryl is unsubstituted or substituted at one or more substitutable positions. with a group that is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, OPro, halo, C1-C6 haloalkyl, or C1-C6 haloalkoxy; and wherein each heterocycloalkyl group is pyrrolidinyl, imidazolidinyl, oxazolidinyl, thiazolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, or morpholinyl, and each heterocycloalkyl is unsubstituted or substituted at one or more positions substitutable with a group that is independently C1-C6 alkyl, C2-C6, C2-C6 alkynyl, C1-C6 alkoxy, OPro, halo, C1-C6 haloalkyl or C1-C6 haloalkoxy; R14 is H or OH; and R25 is OH |
| priorityDate | 2013-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 88.