http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2748242-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_073119acbd235b93306fa836bdf25b6b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H5-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-46 |
| filingDate | 2015-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a93949c302f6286c2f8e9d18c5a0151 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b23d696267aa10b0da4c61a80ffde6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbd13c19f56dc48cd2307f16cf713f41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fad1a0136ec2b1755b23026106627dd9 |
| publicationDate | 2020-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2748242-T3 |
| titleOfInvention | High purity miglustat preparation procedure |
| abstract | A process for the preparation of crystalline miglustat of formula (I) comprising the steps of: ** Formula ** (1) reacting 2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin hydrochloride of formula (V) with n-butyraldehyde and sodium cyanoborohydride in an organic solvent to prepare 2,3,4,6-tetra-O-benzyl-N-butyl-1-deoxynojirimycin hydrochloride of formula (VI); ** Formula ** (2) react 2,3,4,6-tetra-O-benzyl-N-butyl-1-deoxynojirimycin hydrochloride of formula (VI) with hydrogen in the presence of 10% Pd / C and HCl to producing the hydrochloric salt of miglustat of formula (III); ** Formula ** (3) dissolving the hydrochloric salt of miglustat of formula (III) in a first solvent and adding an organic base; (4) optionally removing the first solvent, and (5) adding a second solvent to crystallize miglustat of formula (I); wherein none of steps (1) to (5) involve the use of any flash column or ion exchange column chromatography. |
| priorityDate | 2014-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.