| abstract |
A liquid formulation of a long-acting oxyntomodulin-derived conjugate, comprising a pharmacologically active amount of a long-lasting oxy-modulin-derived conjugate in which the oxy-modulululin-derived derivative conjugate comprises an oxintomodulin derivative, which is a physiologically active peptide, which it comprises the amino acid sequence of any one of SEQ ID NO: 24, 25 or 26; an Fc region of immunoglobulin; and a non-peptidyl polymer, in which the non-peptidyl polymer covalently binds the oxynthomodulin derivative and the immunoglobulin Fc region, and an albumin-free stabilizer, in which the stabilizer contains a buffer having a pH ranging from 4.8 at 6.0, one or more sugar alcohols selected from mannitol and sorbitol and polysorbate 20. |