http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2746756-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2014-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eac9f18b127f51084a1b4b07dc9e6356 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_929b318e94c2e38925f8328e5f407510 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22265d1fc44fd13f03680f63ec61cac1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6535263e1a4dcd82b9022a7515a27a59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_280afd835729eaf123ca8be1be48dc8c |
| publicationDate | 2020-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2746756-T3 |
| titleOfInvention | Derivatives of 6- [4- (1H-imidazol-2-yl) piperidin-1-yl] pyrimidin-4-amine as modulators of kinase activity |
| abstract | Compound selected from the group consisting of: 4-amino-6- {3,4-cis-4- [1- (2-azetidin-1-yl-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl ) -1H-imidazol-2-yl] -3-fluoropiperidin-1-yl} -pyrimidin-5-carbonitrile (racemic) ("1"); 4-amino-6- {3,4-cis-4- [1- (2-azetidin-1-yl-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2- yl] -3-fluoropiperidin-1-yl} -pyrimidin-5-carboxamide (racemic) ("2"); 4-amino-6 - [(3R, 4S) -4- [1- [2- (azetidin-1-yl) ethyl] -4- [4-fluoro-3- (trifluoromethyl) phenyl] imidazol-2-yl ] -3-fluoro-1- piperidyl] pyrimidin-5-carboxamide (chiral) ("3"); 4-amino-6 - [(3S, 4R) -4- [1- [2- (azetidin-1-yl) ethyl] -4- [4-fluoro-3- (trifluoromethyl) phenyl] imidazol-2-yl ] -3-fluoro-1- piperidyl] pyrimidin-5-carboxamide (chiral) ("4"); 4-amino-6- {3,4-cis-4- [1- (2-azetidin-1-yl-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2- yl] -3-methyl-piperidin-1-yl} -pyrimidin-5-carbonitrile (racemic) ("5"); 4-amino-6- {3,4-cis-4- [1- (2-azetidin-1-yl-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2- yl] -3-methyl-piperidin-1-yl} -pyrimidin-5-carboxamide (racemic) ("6"); 4-amino-6- {3,4-trans-4- [1- (2-azetidin-1-yl-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2- yl] -3-fluoro-piperidin-1-yl} -pyrimidin-5-carbonitrile (racemic) ("7"); 4-amino-6- {3,4-trans-4- [1- (2-azetidin-1-yl-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2- yl] -3-fluoro-piperidin-1-yl} -pyrimidin-5-carboxamide (racemic) ("8"); 4-amino-6- {3,4-cis-4- [1- (2-dimethylaminoethyl) -4- (4-fluoro-3-methyl-phenyl) imidazol-2-yl] -3-fluoro-1- piperidil]} - pyrimidin-5-carbonitrile (racemic) ("9"); 6- {3,4-cis-4- [1- (2-azetidin-1-yl-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2-yl] -3 -fluoro-piperidin-1-yl} -5-chloropyrimidin-4-ylamine (racemic) ("10"); 6- {3,4-trans-4- [1- (2-azetidin-1-yl-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2-yl] -3 -fluoro-piperidin-1-yl} -5-chloropyrimidin-4-ylamine (racemic) ("11"); 5-chloro-6- {3,4-cis-4- [1- (2-dimethylamino-ethyl) -4- (4-fluoro-3-methyl-phenyl) -1H-imidazol-2-yl] - 3-fluoro-piperidin-1-yl} -pyrimidin-4-ylamine (racemic) ("12"); 6- {3,4-cis-4- [1- (2-azetidin-1-yl-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2-yl] -3 -fluoro-piperidin-1-yl} -5-ethylpyrimidin-4-ylamine (racemic) ("13"); 4-amino-6- {3,4-cis-4- [1- (2-dimethylamino-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2-yl] -3 -fluoro-piperidin-1-yl} -pyrimidin-5-carbonitrile (racemic) ("14"); 4-amino-6- {3,4-cis-4- [1- (2-dimethylamino-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2-yl] -3 -fluoro-piperidin-1-yl} -pyrimidin-5-carbonitrile (racemic) ("15"); 6- {3,4-cis-4- [1- (2-azetidin-1-yl-ethyl) -4- (4-fluoro-3-trifluoromethyl-phenyl) -1H-imidazol-2-yl] -3 -fluoro-piperidin-1-yl} -5-ethoxypyrimidin-4-ylamine (racemic) ("16"), or pharmaceutically acceptable salts, solvates or solvates of salts thereof. |
| priorityDate | 2013-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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