abstract |
A monoclonal antibody or antigen-binding fragment thereof that binds to the human CGRP receptor, said human CGRP receptor comprising a human CRLR polypeptide and a human RAMP1 polypeptide, wherein the monoclonal antibody or antigen-binding fragment thereof binds to an epitope formed from amino acid residues of both CRLR and RAMP1 polypeptides, and in which the monoclonal antibody or antigen-binding fragment thereof competes for binding to the human CGRP receptor with a reference antibody, said antibody comprising Reference (i) a heavy chain variable region comprising a sequence selected from the group consisting of SEQ ID NO: 161, 163, 164, 166 and 168; and (ii) a light chain variable region comprising a sequence selected from the group consisting of SEQ ID NO: 140, 143, 146, 148 and 150. |