http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2746255-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_015b06914223e1628bc6a0b3d09dcde5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad68395cc506624ac5501658a6644489 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_373a9b7fb8f054922fc382f5f189aad8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e1dfcbdcafbe3a4a72ef04553310205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-307 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-2208 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-307 |
| filingDate | 2015-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f91bb05148498834cad3a5b3d7f901f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_345f686c426b84e571e467374315ccad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cccafa064fcf620ab1b0fe74bc25aad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4b6d0cb10fef76dcac3b1a09ecb8bb9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1864549a4f058aba10441ac8804e2e9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b738faf5280a62ba946d1f450d310b8b |
| publicationDate | 2020-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2746255-T3 |
| titleOfInvention | Organotin reagents supported on ionic liquid for the manufacture of radiopharmaceuticals |
| abstract | Compound of formula (I) ** Formula ** in which: X- represents an anion, preferably X- represents an anion selected from the group comprising halide, acetate, trifluoroacetate, triflate (Tf), NTf2-, alkylsulfate, sulfonate, tetrafluoroborate (BF4-), tetraarylborate, hexafluorophosphate (PF6-), NO3-, SbF6-, prolinate, hydroxide, hydrogen sulfate, tetrachloroferrate, aluminum tetrachloride, perfluorobutyl sulfonate, p-toluenesulfonate, phosphate and dihydrogen more preferably X represents BF4-, PF6-, Cl-, Br-, I-, NTf2-, even more preferably X- represents BF4-, PF6- or Br-; n represents an integer ranging from 3 to 10, preferably n represents 4, 5, 6, 7 or 8, more preferably n represents 6; R1 represents an alkyl group, a PEG chain, preferably R1 represents methyl, ethyl, n-butyl; R2 and R3 each independently represent an alkyl group, preferably R2 and R3 are both n-butyl; R5 represents H, alkyl or aryl, preferably H, methyl or phenyl; R4 represents: - an aryl vector; or - a group selected from aryl and heteroaryl substituted with one or more -LM substituents in which: L represents a single bond or a linker selected from aryl, heteroaryl, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkynyl or a combination of the same; said groups are optionally substituted with at least one group selected from oxo, thioxo, hydroxyl, ether, carboxylic acid, ester, alkyl, cycloalkyl, alkenyl, cycloalkenyl, heterocyclyl, alkynyl, cycloalkynyl, amine, amide, guanidine, imino, nitro, nitrile , azide, sulfhydryl, sulfide, thioester, thioether, sulfite, sulfate, phosphine, phosphite, phosphate, halogen; said groups are optionally interrupted or terminated by -O-, -S-, -NR6- where R6 is H or alkyl, or a combination thereof; and optionally, L further comprises a residue of a reactive group through which L is attached to M; M represents: a reactive function selected from carboxylic acid, nitrile, ester, activated ester, aldehyde, acetal, ketone, ketal, alkyne, azide, alkene, diene, maleimide, protected maleimide, hydroxyl, phenol, 2-aminophenol, thiol, thioester , thioether, thiosulfonate, primary amine, secondary amine, tertiary amine, alkoxyamine, aniline, amide, phosphine, alkyl phosphate, isocyanates, isothiocyanates, hydrazide, hydrazine, tosylate ester, vinyl sulfone, carbamate, carbonate ester, 4-phenyl- 1,2,4-triazole-3,5-dione, sulfide, azidoalkyl, and azidoaryl; or a bioactive group selected from amino acid, biogenic amine, peptide, heteropeptide, protein, antibody or fragment thereof, monobody, afficbody, antibody construct such as, for example, minibody or diabody, saccharide, polysaccharide, benzylguanine, biotin, avidin, nucleotide, oligonucleotide, microRNA, hapten, aptamer, ligand, enzyme, enzyme substrate, steroid, hormone, porphyrin, neurotransmitters, sympathomimetic drug, vitamin, phosphonate, nanocarrier such as, for example, nanocapsules, liposomes, dendrimers, carbon nanotubes and combinations thereof; said aryl or heteroaryl is optionally further substituted with one or more substituents selected from hydroxyl; linear, cyclic, or branched alkyl comprising 1, 2, 3, 4, 5, or 6 carbon atoms; aryl; heteroaryl; heterocyclyl; arylheterocyclyl; alkoxy; halogen; nitro; cyano azido; aldehyde; boronate; phenyl; CF3; -CH (OH) (CF3); - CH (OCH2OCH3) (CF3); methylenedioxy; ethylenedioxy; SO2NRR ', NRR', COOR, CONRR ', NRCOR' wherein R and R 'are each independently selected from the group consisting of H, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkynyl, and aryl; wherein when R4 is an aryl vector, it is selected from: ** Formula ** |
| priorityDate | 2014-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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