abstract |
Vaccine comprising an avian herpesvirus vector, an oligodeoxynucleotide and a pharmaceutically acceptable carrier, wherein the avian herpesvirus vector comprises a heterologous nucleotide sequence encoding an antigen of a microorganism that is pathogenic to birds, wherein the oligodeoxynucleotide is an avian Toll-like receptor (TLR) 21 agonist and wherein the TLR21 receptor agonist has the general formula: 5'- [N1]x [N7]r {N3 [N4]p C G [N5]q N6} n [N8]s [N2]z -3', where: N1 = C or G, N2 = C or G, N3 = T, C or G, N4 = C or T, provided that when N3 = C, then N4 = T, N5 = C or T, N6 = A, T, G or C, N7 = A, T, C or G, N8 = A, T, C or G, x = 3-10, n = 2 -100, z = 0-10, r = 0-8, provided that when N7 = T, then r = 1-25, p = 1-6, provided that when N4 = T, then p = 1-25, q = 1-6, provided that when N5 = T, then q = 1-25, and s = 0-8, provided that when N8 = T, then s = 1-25. |