| abstract |
A substituted indole derivative of Formula (I), ** Formula ** where: R1 represents hydrogen; R2 represents hydrogen; R3 represents the substituted imidazol-5-yl of Formula (II) ** Formula ** where: X represents hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C2-C4 alkenyl, C1-C4 alkoxy, methoxy-C1-C4 alkyl, C6-C10 aryl, or C6-C10 aryl-C1-C4 alkyl; and Z represents hydrogen; R4 represents hydrogen, bromine or methoxy; R5 represents hydrogen, halogen, methyl, hydroxy, methoxy, benzyloxy, cyano or amido; R6 represents hydrogen or bromine; R7 represents hydrogen, fluorine or methyl; where the halogen is selected from fluorine, chlorine, bromine and iodine; or its stereoisomers, mixtures of stereoisomers in any proportion, tautomers, solvates, including hydrates, or pharmaceutically acceptable salts thereof, for use in the treatment of a disease or disorder selected from Rett syndrome, Fragile X syndrome, disorders of the mood including depression, anxiety, sleep disorders, intestinal disorders, pain, schizophrenia, inflammatory processes in the CNS, dementia, Alzheimer's disease, autistic disorder and other neuropsychiatric disorders. |