abstract |
An isolated human monoclonal antibody that binds to human CD20, and comprising: (i) CDR1, CDR2 and CDR3 heavy chain regions having the amino acid regions set forth in SEQ ID NO: 13, 14 and 15; and light chain CDR1, CDR2 and CDR3 regions having the amino acid regions set forth in SEQ ID NO: 16, 17, and 18; (ii) CDR1, CDR2 and heavy chain CDR3 regions having the amino acid regions set forth in SEQ ID NO: 19, 20 and 21; and light chain CDR1, CDR2 and CDR3 regions having the amino acid regions set forth in SEQ ID NO: 22, 23 and 24; or (iii) CDR1 and CDR3 heavy chain regions having the amino acid regions set forth in SEQ ID NO: 25, 26 and 27; and CDR1, CDR2 and light chain CDR3 regions having the amino acid regions set forth in SEQ ID NO: 28, 29, and 30; for use in a method of treating or preventing multiple sclerosis. |