| abstract |
A double-target antibody to VEGFR-2 and DLL4 that comprises a DLL4 antagonist, which is linked to a terminal of a VEGFR-2-binding antibody, in which the antibody that binds to VEGFR- 2 comprises a variable region of the heavy chain comprising a sequence selected from the group consisting of SEQ ID NO: 1 to 3, and a variable region of the light chain comprising a sequence selected from the group consisting of SEQ ID NO: : 4 to 6, where the DLL4 antagonist is the 11th and 12th calcium-binding EGF-like domain of human Notch1, and where the DLL4 antagonist is bound to the N-terminus of the variable region of the chain light antibody that binds to VEGFR-2. |