| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f85af810578fac3d697eb58690a6f7c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-22 |
| filingDate |
2013-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d2f371f12764ab7d2057b93753a469e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a940dd405b638121fe083533f080dc6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dfb2bb3c3f71e9bbf9d124b8ba4940e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a448b456f2e510c94bc66c1c53db3896 |
| publicationDate |
2020-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2742287-T3 |
| titleOfInvention |
Monoclonal antibodies against growth differentiation factor 15 (GDF-15) |
| abstract |
Monoclonal antibody capable of binding human GDF-15, or an antigen-binding portion thereof capable of binding human GDF-15, wherein: i) the heavy chain variable domain comprises a CDR3 region comprising the sequence of amino acids of SEQ ID NO: 5 or an amino acid sequence at least 90% identical thereto, and in which the light chain variable domain comprises a CDR3 region comprising the amino acid sequence of SEQ ID NO: 7 or an amino acid sequence at least 85% identical thereto, and wherein the antibody or antigen-binding portion thereof is capable of inhibiting the growth of cancer in a mammal, or ii) the binding is a binding to a discontinuous or conformational epitope in human GDF-15 that is composed of the amino acid sequences of SEQ ID NO: 25 and SEQ ID NO: 26, and in which the antibody or antigen-binding portion thereof is capable of inhibit the growth of cancer in a mammal. |
| priorityDate |
2012-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |