abstract |
A continuous process to prepare a tablet comprising Compound 1 comprising the steps of: a) mixing Compound 1, a filler and a disintegrant in a blender to form a mixture; b) preparing a granulation solution with water, a binder and a surfactant; c) feeding the mixture from step a) into a continuous twin screw granulator while adding the granulation solution from step b) to produce granules; d) drying the granules from step c) and milling them; e) mixing the ground granules from step d) with a filler, disintegrant and lubricant to form a mixture; and f) compressing the mixture from step e) into a tablet; wherein Compound 1 is 3- (6- (1- (2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) benzoic acid. |