http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2739697-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-537 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08K3-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-22 |
| filingDate | 2015-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bd7adedbbc6c6facd79fa3637d02fa9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14d445f4b12dda783b31958c78c5d6db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50366cd58011bce2d6a5f615cd849f07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efaaffc2280e0e52e838cd8afc7a6ae5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de8a2b105ddd9d3f22c209c132805a4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d7be76cc778f8059e3d06e747fe29df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d034ffd1ac9b832de274274930b1a1d8 |
| publicationDate | 2020-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2739697-T3 |
| titleOfInvention | New compounds and derivatives of spiro [3H-indole-3,2-pyrrolidin] -2 (1H) -one as MDM2-p53 inhibitors |
| abstract | A compound of formula (I) ** Formula ** wherein R1 is a group, optionally substituted with one or more, identical or different Rb1 and / or Rc1, selected from C1-6 alkyl, C2-6 alkenyl, C2- alkynyl 10 6, C1-6 haloalkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rb1 is independently selected from -ORc1, -NRc1Rc1, halogen, -CN, -C (O) Rc1, -C (O) ORc1, - C (O) NRc1'Rc1, -S (O) 2Rc1, -S ( O) 2NRc1Rc1, -NHC (O) Rc1 and -N (C1-4alkyl) C (O) Rc1; each Rc1 independently of one another represents hydrogen or a group, optionally substituted by one or more, identical or different Rd1 and / or Re1, selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, cycloalkyl C3-7, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rd1 is independently selected from -ORe1, -NRe1Re1, halogen, -CN, -C (O) Re1, -C (O) ORe1, - C (O) NRe1Re1, -S (O) 2Re1, -S (O) 2NRe1Re1, -NHC (O) Re1 and -N (C1-4alkyl) C (O) Re1; each Re1 independently of one another represents hydrogen or a group, optionally substituted with one or more, identical or different Rf1 and / or Rg1, selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, haloalkyl C1-6, cycloalkyl C3-7, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rf1 is independently selected from -ORg1, -NRg1Rg1, halogen, -CN, -C (O) Rg1, -C (O) ORg1, - C (O) NRg1Rg1, -S (O) 2Rg1, -S (O) 2NRg1Rg1, -NHC (O) Rg1 and -N (C1-4alkyl) C (O) Rg1; Each Rg1 is independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; R2 and R3, each independently, is selected from hydrogen, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl, wherein this C6-10 aryl, 5-10 membered heteroaryl and 3 heterocyclyl -10 members is optionally substituted with one or more identical or different Rb2 and / or Rc2; each Rb2 is independently selected from -ORc2, -NRc2Rc2, halogen, -CN, -C (O) Rc2, -C (O) ORc2, - C (O) NRc2Rc2, -S (O) 2Rc2, -S (O) 2NRc2Rc2, -NHC (O) Rc2 and -N (C1-4alkyl) C (O) Rc2; each Rc2 independently of one another represents hydrogen or a group, optionally substituted by one or more, identical or different Rd2 and / or Re2, selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, cycloalkyl C3-6, C4-6 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rd2 is independently selected from -ORe2, -NRe2Re2, halogen, -CN, -C (O) Re2, -C (O) ORe2, - C (O) NRe2Re2, -S (O) 2Re2, -S (O) 2NRe2Re2, -NHC (O) Re2 and -N (C1-4alkyl) C (O) Re2; each Re2 independently of each other represents hydrogen or a group selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-6 cycloalkyl, C4-10 cycloalkenyl, C6-10 aryl, heteroaryl of 5 -10 members and 3-10 membered heterocyclyl; A is selected from 5-6 membered phenyl and heteroaryl; each R4 is independently selected from Ra4 and Rb4; each Ra4 independently of one another is a group, optionally substituted with one or more, identical or different Rb4 and / or Rc4, selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3- cycloalkyl 7, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rb4 is independently selected from -ORc4, -NRc4Rc4, halogen, -CN, -C (O) Rc4, -C (O) ORc4, - C (O) NRc4Rc4, -C (O) NRg4ORc4, -S (O) 2Rc4, -S (O) 2NRc4Rc4, -NHSO2Rc4, -N (C1-4alkyl) SO2Rc4, -NHC (O) Rc4, and - N (C1-4alkyl) C (O) Rc4; each Rc4 independently of one another represents hydrogen or a group, optionally substituted with one or more, identical or different Rd4 and / or Re4, selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, cycloalkyl C3-7, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rd4 is independently selected from -ORe4, -NRe4Re4, halogen, -CN, -C (O) Re4, -C (O) ORe4, - C (O) NRe4Re4, -C (O) NRg4ORe4, -S (O) 2Re4, -S (O) 2NRe4Re4, -NHC (O) Re4 and -N (C1-4alkyl) C (O) Re4; each Re4 independently of one another represents hydrogen or a group, optionally substituted with one or more, identical or different Rf4 and / or Rg4, selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, cycloalkyl C3-7, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rf4 is independently selected from -ORg4, -NRg4Rg4, halogen, -CN, -C (O) Rg4, -C (O) ORg4, - C (O) NRg4Rg4, -C (O) NRg4ORg4, -S (O) 2Rg4, -S (O) 2NRg4Rg4, -NHC (O) Rg4 and -N (C1-4alkyl) C (O) Rg4; each Rg4 is independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; r represents the number 0, 1, 2, or 3 R5 and R6, each independently, is selected from hydrogen, C1-4alkyl, and C1-4alkyl; n represents the number 0 or 1; Each R7 is independently selected from halogen, C1-4alkyl, -CN, C1-4alkyl, -O4-4alkyl, and -Ohaloalkyl-C1-4; q represents the number 0, 1, 2 or 3; W, X and Y are each independently selected from -N = and -CH = with the proviso that the hydrogen in each -CH = can be replaced with one R7 substituent if present and that a maximum of two of W, X and Y can be -N =; V is oxygen or sulfur; or a salt thereof. |
| priorityDate | 2014-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 310.